About the Authors
- Eliza Wyszko
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Affiliation Institute of Bioorganic Chemistry of the Polish Academy of Sciences, Poznan, Poland
- Maciej Szymański
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Current address: Institute of Molecular Biology and Biotechnology, Faculty of Biology, A. Mickiewicz University Poznan, Poznan, Poland
Affiliation Institute of Bioorganic Chemistry of the Polish Academy of Sciences, Poznan, Poland
- Heinz Zeichhardt
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Affiliation Charite - University Medicine Berlin, Campus Benjamin Franklin, Institute for Virology, Berlin, Germany
- Florian Müller
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Affiliation Pentafolium-Soft, Rosengarten, Germany
- Jan Barciszewski
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Affiliation Institute of Bioorganic Chemistry of the Polish Academy of Sciences, Poznan, Poland
- Volker A. Erdmann
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* E-mail: vae@zedat.fu-berlin.de
Affiliation Institute for Chemistry and Biochemistry, Free University Berlin, Berlin, Germany
Competing Interests
The authors have the following patent applications: “Pharmazeutische Zusammensetzung zur Behandlung von Nebenwirkungen durch Gabe von Spiegelmeren” PCT/DE 2010/00159; “Pharmazeutische Zusammensetzung enthaltend L-DNA” DE 10 2010 056 610.1; and “Spiegelselektion und Spiegelevolution von Nukleinsäuren” PCT/EP 97/04726. One author (FM) is the owner of the Pentafolinum-Soft company and he is collaborating with all coauthors on the 3D modeling of Spiegelzymes. There are no further patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.
Author Contributions
Prepared the human serum donated by a Berlin patient and participated in the discussions of the results: HZ. Developed and designed the three dimensional models for the mirror image ribozymes interacting with the mirror image targets: FM. Conceived and designed the experiments: VAE. Performed the experiments: EW. Analyzed the data: EW MS JB VAE. Contributed reagents/materials/analysis tools: HZ FM. Wrote the paper: VAE JB FM.