Skin Collagen Fiber Molecular Order: A Pattern of Distributional Fiber Orientation as Assessed by Optical Anisotropy and Image Analysis

Juliana Fulan Ribeiro; Eli Heber Martins dos Anjos; Maria Luiza S. Mello; Benedicto de Campos Vidal

doi:10.1371/journal.pone.0054724

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Open Access

Peer-reviewed

Research Article

Skin Collagen Fiber Molecular Order: A Pattern of Distributional Fiber Orientation as Assessed by Optical Anisotropy and Image Analysis

Juliana Fulan Ribeiro,

Affiliation Department of Structural and Functional Biology, Institute of Biology, University of Campinas (Unicamp), Campinas, São Paulo, Brazil
⨯
Eli Heber Martins dos Anjos,

Affiliation Department of Structural and Functional Biology, Institute of Biology, University of Campinas (Unicamp), Campinas, São Paulo, Brazil
⨯
Maria Luiza S. Mello,

Affiliation Department of Structural and Functional Biology, Institute of Biology, University of Campinas (Unicamp), Campinas, São Paulo, Brazil
⨯
Benedicto de Campos Vidal

* E-mail: camposvi@unicamp.br

Affiliation Department of Structural and Functional Biology, Institute of Biology, University of Campinas (Unicamp), Campinas, São Paulo, Brazil
⨯

Skin Collagen Fiber Molecular Order: A Pattern of Distributional Fiber Orientation as Assessed by Optical Anisotropy and Image Analysis

Juliana Fulan Ribeiro,
Eli Heber Martins dos Anjos,
Maria Luiza S. Mello,
Benedicto de Campos Vidal

Published: January 18, 2013
https://doi.org/10.1371/journal.pone.0054724

About the Authors

Juliana Fulan Ribeiro

Affiliation Department of Structural and Functional Biology, Institute of Biology, University of Campinas (Unicamp), Campinas, São Paulo, Brazil

Eli Heber Martins dos Anjos

Affiliation Department of Structural and Functional Biology, Institute of Biology, University of Campinas (Unicamp), Campinas, São Paulo, Brazil

Maria Luiza S. Mello

Affiliation Department of Structural and Functional Biology, Institute of Biology, University of Campinas (Unicamp), Campinas, São Paulo, Brazil

Benedicto de Campos Vidal

* E-mail: camposvi@unicamp.br

Affiliation Department of Structural and Functional Biology, Institute of Biology, University of Campinas (Unicamp), Campinas, São Paulo, Brazil

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BCV. Performed the experiments: JFR EHMA BCV. Analyzed the data: JFR MLSM BCV. Contributed reagents/materials/analysis tools: BCV. Wrote the paper: MLSM BCV. Form and intrinsic birefringence evaluation, illustration adequacy for publication: JFR. Image analysis, figure documentation: BCV. Material preparation and figure 3 conception: EHMA.

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Collagens
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Polarized light microscopy
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Image analysis
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Refractive index
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Anisotropy
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Tendons
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Focal planes
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Optical properties
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