About the Authors

Weibin Zha

Affiliations Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, United States of America, Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, P.R. China

Guangji Wang

wangguangji01@gmail.com (GW); hzhou@vcu.edu (HZ)

Affiliation Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, P.R. China

Weiren Xu

Affiliation Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, Tianjin, P.R. China

Xuyuan Liu

Affiliations Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, Tianjin, P.R. China, Basic Medical College, Tianjin Medical University, Tianjin, P.R. China

Yun Wang

Affiliation Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, United States of America

Beth S. Zha

Affiliation Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, United States of America

Jian Shi

Affiliation Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, P.R. China

Qijin Zhao

Affiliation Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, P.R. China

Phillip M. Gerk

Affiliation Department of Pharmaceutics, Virginia Commonwealth University, Richmond, Virginia, United States of America

Elaine Studer

Affiliation Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, United States of America

Phillip B. Hylemon

Affiliations Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, United States of America, Department of Internal Medicine/Gastroenterology and McGuire Veterans Affairs Medical Center, Richmond, Virginia, United States of America

William M. Pandak Jr

Affiliation Department of Internal Medicine/Gastroenterology and McGuire Veterans Affairs Medical Center, Richmond, Virginia, United States of America

Huiping Zhou

wangguangji01@gmail.com (GW); hzhou@vcu.edu (HZ)

Affiliations Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, United States of America, Department of Internal Medicine/Gastroenterology and McGuire Veterans Affairs Medical Center, Richmond, Virginia, United States of America, School of Pharmacy, Wenzhou Medical College, Wenzhou, P.R. China

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WZ GW PG HZ. Performed the experiments: WZ WX XL YW JS QZ. Analyzed the data: WZ. Wrote the paper: WZ BZ ES PH WP HZ.