A Single Valine Residue Plays an Essential Role in Peripherin/rds Targeting to Photoreceptor Outer Segments

Raquel Y. Salinas; Sheila A. Baker; Sidney M. Gospe III; Vadim Y. Arshavsky

doi:10.1371/journal.pone.0054292

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Open Access

Peer-reviewed

Research Article

A Single Valine Residue Plays an Essential Role in Peripherin/rds Targeting to Photoreceptor Outer Segments

Raquel Y. Salinas,

Affiliation Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Sheila A. Baker,

Affiliation Department of Biochemistry, University of Iowa, Iowa City, Iowa, United States of America
⨯
Sidney M. Gospe III,

Affiliations Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, United States of America, Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Vadim Y. Arshavsky

* E-mail: vadim.arshavsky@duke.edu

Affiliations Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, United States of America, Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯

A Single Valine Residue Plays an Essential Role in Peripherin/rds Targeting to Photoreceptor Outer Segments

Raquel Y. Salinas,
Sheila A. Baker,
Sidney M. Gospe III,
Vadim Y. Arshavsky

Published: January 14, 2013
https://doi.org/10.1371/journal.pone.0054292

About the Authors

Raquel Y. Salinas

Affiliation Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, United States of America

Sheila A. Baker

Affiliation Department of Biochemistry, University of Iowa, Iowa City, Iowa, United States of America

Sidney M. Gospe III

Affiliations Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, United States of America, Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, United States of America

Vadim Y. Arshavsky

* E-mail: vadim.arshavsky@duke.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RYS SAB SMG VYA. Performed the experiments: RYS SAB SMG. Analyzed the data: RYS SAB SMG VYA. Wrote the paper: RYS VYA.

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Peripherin
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Genetically modified animals
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Photoreceptors
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Mouse models
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Xenopus
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Cytoskeletal proteins
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Protein sequencing
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Valine
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