About the Authors

Justyna Siwy

Contributed equally to this work with: Justyna Siwy, Carlamaria Zoja

Affiliations Mosaiques Diagnostics, Hannover, Germany, Charite- Universitaetsmedizin Berlin, Germany

Carlamaria Zoja

Contributed equally to this work with: Justyna Siwy, Carlamaria Zoja

Affiliation Mario Negri Institute for Pharmacological Research, Centro Anna Maria Astori, Bergamo, Italy

Julie Klein

Affiliation School of Computer Science, University of Manchester, United Kingdom

Ariela Benigni

Affiliation Mario Negri Institute for Pharmacological Research, Centro Anna Maria Astori, Bergamo, Italy

Wiliam Mullen

Affiliation e BHF Glasgow Cardiovascular Research Centre, University of Glasgow, United Kingdom

Bernd Mayer

Affiliation Emergentec Biodevelopment GmbH, Vienna, Austria

Harald Mischak

Affiliations Mosaiques Diagnostics, Hannover, Germany, e BHF Glasgow Cardiovascular Research Centre, University of Glasgow, United Kingdom

Joachim Jankowski

Affiliation Charite- Universitaetsmedizin Berlin, Germany

Robert Stevens

Affiliation School of Computer Science, University of Manchester, United Kingdom

Antonia Vlahou

Affiliation Biomedical Research Foundation, Academy of Athens, Greece

Sophia Kossida

Affiliation Biomedical Research Foundation, Academy of Athens, Greece

Paul Perco

Affiliation Emergentec Biodevelopment GmbH, Vienna, Austria

Ferdinand H. Bahlmann

ferdinandbahlmann@web.de

Affiliation Department of Internal Medicine, Saarland University Hospital, Homburg, Germany

Competing Interests

JS is an employee of Mosaiques Diagnostics GmbH. HM is founder and co-owner of Mosaiques Diagnostics, a company commerically involved in development and application of diagnostics. There are no patents, products in development, or marketed products to declare in relation to this manuscript. PP is an employee of emergentec biodevelopment GmbH. BM is founder and co-owner of emergentec biodevelopment GmbH, a company commercially involved in development and application of software for Life Sciences data management and analysis. There are no patents, products in development, or marketed products to declare in relation to this manuscript. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: CZ AB BM HM JJ JPS PP FHB. Performed the experiments: JS CZ AB FHB. Analyzed the data: JS CZ JK AB WM BM HM JJ RS AV SK PP FHB. Contributed reagents/materials/analysis tools: JS CZ JK AB WM BM HM JJ RS AV SK PP FHB. Wrote the paper: JS CZ BM HM JJ AV PP FHB.