About the Authors

Pascal Jourdain

pascal.jourdain@epfl.ch (PJ); pierre.marquet@chuv.ch (PM)

Affiliation Brain and Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

Daniel Boss

Affiliation Brain and Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

Benjamin Rappaz

Affiliation Brain and Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

Corinne Moratal

Affiliation Brain and Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

Maria-Clemencia Hernandez

Affiliation Hoffmann-La Roche, Basel, Switzerland

Christian Depeursinge

Affiliation Institute of Applied Optics, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

Pierre Julius Magistretti

Contributed equally to this work with: Pierre Julius Magistretti, Pierre Marquet

Affiliations Brain and Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, Center for Psychiatric Neuroscience Department, Lausanne University Hospital, Prilly, Switzerland

Pierre Marquet

Contributed equally to this work with: Pierre Julius Magistretti, Pierre Marquet

pascal.jourdain@epfl.ch (PJ); pierre.marquet@chuv.ch (PM)

Affiliations Brain and Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, Center for Psychiatric Neuroscience Department, Lausanne University Hospital, Prilly, Switzerland

Competing Interests

The authors have the following interests. M.C. Hernandez is employed by F. Hoffmann-La Roche AG, who generously provided the HEK293 cells for this study. Christian Depeursinge, Pierre J. Magistretti and Pierre Marquet are co-founders of Lyncée Tec. The persons mentioned in this statement are part of university research groups, and have participated seven years ago in the foundation of the Lyncée Tec company, which commercializes products related to the technology employed in this study. The study has been performed independently of Lyncée Tec in the academic laboratories related to these three persons, although Lyncée Tech SA (www.lynceetec.com) did provide technological assistance (Microscope: DHMT 1000). There are no further patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: PJ PM. Performed the experiments: PJ DB BR CM. Analyzed the data: PJ DB PM. Contributed reagents/materials/analysis tools: DB MCH. Wrote the paper: PJ CD PJM PM.