About the Authors
- Marie-José C. van Lierop
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Contributed equally to this work with: Marie-José C. van Lierop, Wynand Alkema
* E-mail: mariejose.vanlierop@merck.com
Affiliation Department of Immune Therapeutics, MSD, Oss, The Netherlands
- Wynand Alkema
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Contributed equally to this work with: Marie-José C. van Lierop, Wynand Alkema
Affiliation Department of Molecular Design and Informatics, MSD, Oss, The Netherlands
- Anke J. Laskewitz
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Affiliation Department of Pediatrics, Center for Liver Digestive and Metabolic Diseases, University Medical Center Groningen, Groningen, The Netherlands
- Rein Dijkema
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Affiliation Molecular Pharmacology Department, MSD, Oss, The Netherlands
- Hans M. van der Maaden
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Affiliation Molecular Pharmacology Department, MSD, Oss, The Netherlands
- Martin J. Smit
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Affiliation Molecular Pharmacology Department, MSD, Oss, The Netherlands
- Ralf Plate
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Affiliation Medicinal Chemistry Department, MSD, Oss, The Netherlands
- Paolo G. M. Conti
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Affiliation Medicinal Chemistry Department, MSD, Oss, The Netherlands
- Christan G. J. M. Jans
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Affiliation Medicinal Chemistry Department, MSD, Oss, The Netherlands
- C. Marco Timmers
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Affiliation Women's Health Department, MSD, Oss, The Netherlands
- Constant A. A. van Boeckel
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Affiliation Medicinal Chemistry Department, MSD, Oss, The Netherlands
- Scott J. Lusher
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Affiliation Department of Molecular Design and Informatics, MSD, Oss, The Netherlands
- Ross McGuire
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Affiliation Department of Molecular Design and Informatics, MSD, Oss, The Netherlands
- Rene C. van Schaik
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Affiliation Department of Molecular Design and Informatics, MSD, Oss, The Netherlands
- Jacob de Vlieg
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Affiliation Department of Molecular Design and Informatics, MSD, Oss, The Netherlands
- Ruben L. Smeets
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Affiliation Department of Immune Therapeutics, MSD, Oss, The Netherlands
- Claudia L. Hofstra
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Affiliation Department of Immune Therapeutics, MSD, Oss, The Netherlands
- Annemieke M. H. Boots
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Affiliation Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, The Netherlands
- Marcel van Duin
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Affiliation Women's Health Department, MSD, Oss, The Netherlands
- Benno A. Ingelse
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Affiliation Toxicology and Drug Disposition, MSD, Oss, The Netherlands
- Willem G. E. J. Schoonen
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Affiliation Toxicology and Drug Disposition, MSD, Oss, The Netherlands
- Aldo Grefhorst
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Affiliation Department of Pediatrics, Center for Liver Digestive and Metabolic Diseases, University Medical Center Groningen, Groningen, The Netherlands
- Theo H. van Dijk
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Affiliation Department of Pediatrics, Center for Liver Digestive and Metabolic Diseases, University Medical Center Groningen, Groningen, The Netherlands
- Folkert Kuipers
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Affiliations Department of Pediatrics, Center for Liver Digestive and Metabolic Diseases, University Medical Center Groningen, Groningen, The Netherlands, Department of Laboratory Medicine, University Medical Center Groningen, Groningen, The Netherlands
- Wim H. A. Dokter
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Affiliation Department of Immune Therapeutics, MSD, Oss, The Netherlands
Competing Interests
The authors have read the journal's policy and have the following conflicts. The following co-authors are or were employees at Merck at the time the work described in this manuscript was performed: M.J.C. van Lierop, W. Alkema, R. Dijkema, H. van der Maaden, M.J. Smit, R. Plate, P.G.M. Conti, C.G.J.M. Jans, C.M. Timmers, C.A.A. van Boeckel, S.J. Lusher, R. McGuire, R.C. van Schaik, J. de Vlieg, R. Smeets, C.L. Hofstra, A.M.H. Boots, M. van Duin, B.A. Ingelse, W.G.J.E. Schoonen and W. Dokter. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. The research described in this manuscript was funded by Top Institute Pharma (TIPharma), a nonprofit organization that catalyzes medicine development by founding partnerships between academia and industry. The co-author A.J. Laskewitz was employed by TIPharma. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. There are no patents, products in development or marketed products to declare.
Author Contributions
Conceived and designed the experiments: MvL WA AL RD HvdM RP PC CJ SL RS CH AB WS AG TvD WD. Performed the experiments: MvL WA AL RD HvdM RP PC CJ SL RS CH WS AG TvD FK. Analyzed the data: MvL WA AL RD HvdM RP PC CJ SL RS CH AB WS AG TvD FK WD. Contributed reagents/materials/analysis tools: MvL WA AL RD HvdM MS RP PC CJ CT CvB SL RvS JdV RS CH AB MvD BI WS AG TvD FK WD. Wrote the paper: MvL WA AL RD HvdM RP PC SL RS CH AB WS AG TvD FK WD. Managing and providing tools/scientific input in the research project from their specific discipline: MS CT CvB RM RvS JdV MvD BI FK WD.