About the Authors

Marcella Maddaluno

Contributed equally to this work with: Marcella Maddaluno, Gianluca Grassia

Affiliation Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy

Gianluca Grassia

Contributed equally to this work with: Marcella Maddaluno, Gianluca Grassia

Affiliation Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy

Maria Vittoria Di Lauro

Affiliation Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy

Antonio Parisi

Affiliation Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy

Francesco Maione

Affiliation Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy

Carla Cicala

Affiliation Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy

Daniele De Filippis

Affiliation Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy

Teresa Iuvone

Affiliation Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy

Angelo Guglielmotti

Affiliation Angelini, ACRAF, S.Palomba-Pomezia, Rome, Italy

Pasquale Maffia

Affiliations Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

Nicola Mascolo

ialenti@unina.it (AI); nicoladomenicocferd.mascolo@unina.it (NM)

Affiliation Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy

Armando Ialenti

ialenti@unina.it (AI); nicoladomenicocferd.mascolo@unina.it (NM)

Affiliation Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy

Competing Interests

This study was funded by Angelini, the employer of author Angelo Guglielmotti. Bindarit is an Angelini product. There are no further patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: GG MM AI NM AG. Performed the experiments: GG MM MVDL DDF AP FM. Analyzed the data: GG MM AG AI PM CC TI NM MVDL DDF AP FM. Wrote the paper: GG MM AI NM PM AG.