About the Authors

Yongwook Choi
Gregory E. Sims

Current address: Department of Bioinformatics, Pathway Genomics Corporation, San Diego, California, United States of America

Sean Murphy

Current address: Howard Hughes Medical Institute Janelia Farm Research Campus, Ashburn, Virginia, United States of America

Jason R. Miller
Agnes P. Chan


Affiliation The J. Craig Venter Institute, Rockville, Maryland, United States of America

Competing Interests

The authors have the following competing interests: The authors have developed a new algorithm, PROVEAN (Protein Variation Effect Analyzer), which provides a generalized approach to predict the functional effects of protein sequence variations including single or multiple amino acid substitutions, and in-frame insertions and deletions. The PROVEAN tool is available online at http://provean.jcvi.org. There are no further patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: APC YC GES. Performed the experiments: YC. Analyzed the data: YC GES APC JRM SM. Wrote the paper: APC YC.