Phosphorylation of C3a Receptor at Multiple Sites Mediates Desensitization, β-Arrestin-2 Recruitment and Inhibition of NF-κB Activity in Mast Cells

Kshitij Gupta; Hariharan Subramanian; Andreas Klos; Hydar Ali

doi:10.1371/journal.pone.0046369

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Peer-reviewed

Research Article

Phosphorylation of C3a Receptor at Multiple Sites Mediates Desensitization, β-Arrestin-2 Recruitment and Inhibition of NF-κB Activity in Mast Cells

Kshitij Gupta,

Affiliation Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Hariharan Subramanian,

Affiliation Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Andreas Klos,

Affiliation Institute of Medical Microbiology and Hospital Epidemiology, Medical School Hannover, Hannover, Germany
⨯
Hydar Ali

* E-mail: alih@upenn.edu

Affiliation Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯

Phosphorylation of C3a Receptor at Multiple Sites Mediates Desensitization, β-Arrestin-2 Recruitment and Inhibition of NF-κB Activity in Mast Cells

Kshitij Gupta,
Hariharan Subramanian,
Andreas Klos,
Hydar Ali

Published: October 15, 2012
https://doi.org/10.1371/journal.pone.0046369

About the Authors

Kshitij Gupta

Affiliation Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Hariharan Subramanian

Affiliation Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Andreas Klos

Affiliation Institute of Medical Microbiology and Hospital Epidemiology, Medical School Hannover, Hannover, Germany

Hydar Ali

* E-mail: alih@upenn.edu

Affiliation Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Competing Interests

AK, a co-author of this manuscript, is an Academic Editor of PLOS ONE. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: HA KG. Performed the experiments: KG HS. Analyzed the data: KG HA. Contributed reagents/materials/analysis tools: AK KG HA. Wrote the paper: KG HA.

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Phosphorylation
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Transcription factors
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Mast cells
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Cell degranulation
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Luciferase
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Transfection
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Chemokines
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G protein coupled receptors
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