About the Authors

Daniel S. Kim

Affiliations Department of Medicine, Division of Medical Genetics, University of Washington School of Medicine, Seattle, Washington, United States of America, Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington, United States of America

Ian B. Stanaway

Affiliation Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington, United States of America

Ramakrishnan Rajagopalan

Affiliation Department of Medicine, Division of Medical Genetics, University of Washington School of Medicine, Seattle, Washington, United States of America

Judy C. Bernbaum

Affiliation Division of General Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

Cynthia B. Solot

Affiliation Center for Childhood Communication, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

Nancy Burnham

Affiliation Division of Cardiothoracic Surgery, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

Elaine H. Zackai

Affiliation Division of Genetics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

Robert R. Clancy

Affiliation Division of Neurology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

Susan C. Nicolson

Affiliation Division of Cardiothoracic Anesthesiology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

Marsha Gerdes

Affiliation Division of Psychology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

Deborah A. Nickerson

Affiliation Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington, United States of America

Hakon Hakonarson

Affiliations Center for Applied Genomics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

J. William Gaynor

Affiliation Division of Cardiothoracic Surgery, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

Gail P. Jarvik

pair@u.washington.edu

Affiliations Department of Medicine, Division of Medical Genetics, University of Washington School of Medicine, Seattle, Washington, United States of America, Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JWG GPJ. Performed the experiments: DSK IBS RR. Analyzed the data: DSK IBS RR. Contributed reagents/materials/analysis tools: JCB CBS NB EHZ RRC SCN MG DAN HH JWG GPJ. Wrote the paper: DSK JWG GPJ.