About the Authors

Matthew R. Ginsberg

Affiliation Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio, United States of America

Robert A. Rubin

Affiliation Department of Mathematics, Whittier College, Whittier, California, United States of America

Tatiana Falcone

Affiliation Neurological Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

Angela H. Ting

Affiliation Genomic Medicine Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

Marvin R. Natowicz

natowim@ccf.org

Affiliations Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio, United States of America, Neurological Institute, Cleveland Clinic, Cleveland, Ohio, United States of America, Genomic Medicine Institute, Cleveland Clinic, Cleveland, Ohio, United States of America, Pathology and Laboratory Medicine and Pediatrics Institutes, Cleveland Clinic, Cleveland, Ohio, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MRG MRN. Performed the experiments: MRG. Analyzed the data: MRG RAR TF AHT MRN. Wrote the paper: MRG MRN. Designed subject selection criteria and all experiments: MRG MRN. Provided input on subject selection: TF. Provided input on methylation analysis: AHT. Performed tissue handling: MRG. Performed statistical analyses: MRG RAR. Involvment in data analysis: MRG RAR TF AHT MRN. Wrote the manuscript: MRG MRN. Provided feedback on the manuscript: RAR TF AHT.