About the Authors

Fernando Safdie

Contributed equally to this work with: Fernando Safdie, Sebastian Brandhorst

Affiliation Longevity Institute and Department of Biological Sciences, School of Gerontology, University of Southern California, Los Angeles, California, United States of America

Sebastian Brandhorst

Contributed equally to this work with: Fernando Safdie, Sebastian Brandhorst

Affiliations Longevity Institute and Department of Biological Sciences, School of Gerontology, University of Southern California, Los Angeles, California, United States of America, Centre for Medical Biotechnology, Faculty of Biology, University Duisburg–Essen, Essen, Germany

Min Wei

Affiliation Longevity Institute and Department of Biological Sciences, School of Gerontology, University of Southern California, Los Angeles, California, United States of America

Weijun Wang

Affiliation USC/Norris Neuro-Oncology Program, Neurological Surgery and Pathology, USC Keck School of Medicine, Los Angeles, California, United States of America

Changhan Lee

Affiliation Longevity Institute and Department of Biological Sciences, School of Gerontology, University of Southern California, Los Angeles, California, United States of America

Saewon Hwang

Affiliation Longevity Institute and Department of Biological Sciences, School of Gerontology, University of Southern California, Los Angeles, California, United States of America

Peter S. Conti

Affiliation Department of Radiology, Molecular Imaging Center, USC Keck School of Medicine, Los Angeles, California, United States of America

Thomas C. Chen

Affiliation USC/Norris Neuro-Oncology Program, Neurological Surgery and Pathology, USC Keck School of Medicine, Los Angeles, California, United States of America

Valter D. Longo

vlongo@usc.edu

Affiliation Longevity Institute and Department of Biological Sciences, School of Gerontology, University of Southern California, Los Angeles, California, United States of America

Competing Interests

The authors have read the journal’s policy and have the following conflicts: VDL has founded L-Nutra and is a consultant for Amore Pacific. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials. All other authors declare no competing interests.

Author Contributions

Conceived and designed the experiments: FS SB MW TCC VDL. Performed the experiments: FS SB MW WW CL SH PSC. Analyzed the data: FS SB MW CL TCC VDL. Contributed reagents/materials/analysis tools: PSC TCC VDL. Wrote the paper: FS SB MW DL TCC VDL.