About the Authors

Cory Bystrom

Contributed equally to this work with: Cory Bystrom, Shijun Sheng

Affiliation Cleveland Heart Lab, Cleveland, Ohio, United States of America

Shijun Sheng

Contributed equally to this work with: Cory Bystrom, Shijun Sheng

Affiliation Thermo Scientific, San Jose, California, United States of America

Ke Zhang

Affiliation Quest Diagnostics – Nichols Institute, San Juan Capistrano, California, United States of America

Michael Caulfield

Affiliation Quest Diagnostics – Nichols Institute, San Juan Capistrano, California, United States of America

Nigel J. Clarke

Affiliation Quest Diagnostics – Nichols Institute, San Juan Capistrano, California, United States of America

Richard Reitz

Richard.e.reitz@questdiagnostics.com

Affiliation Quest Diagnostics – Nichols Institute, San Juan Capistrano, California, United States of America

Competing Interests

Cory Bystrom, Shijun Sheng, Ke Zhang, Michael Caulfield, Nigel J. Clarke and Richard Reitz are all employes of the funder Quest Diagnostics. Patent rights for the methods used in this research have been applied for and Quest Diagnostics are offering the tests for IGF-1 and IGF-II as commercial products. Quest Diagnistics may develop additional intellectual property or products in the future that arise from the use of these specific methods in particular patient populations. There are no further patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: CB SS. Performed the experiments: CB SS. Analyzed the data: CB SS KZ RR NC MC. Wrote the paper: CB SS.