About the Authors

Michaela Lang

Contributed equally to this work with: Michaela Lang, Baktybek Kojonazarov

Affiliation University of Giessen and Marburg Lung Center, Giessen, Germany

Baktybek Kojonazarov

Contributed equally to this work with: Michaela Lang, Baktybek Kojonazarov

Affiliation University of Giessen and Marburg Lung Center, Giessen, Germany

Xia Tian

Affiliation University of Giessen and Marburg Lung Center, Giessen, Germany

Anuar Kalymbetov

Affiliation University of Giessen and Marburg Lung Center, Giessen, Germany

Norbert Weissmann

Affiliation University of Giessen and Marburg Lung Center, Giessen, Germany

Friedrich Grimminger

Affiliation University of Giessen and Marburg Lung Center, Giessen, Germany

Axel Kretschmer

Affiliation Bayer HealthCare, Wuppertal, Germany

Johannes-Peter Stasch

Affiliation Bayer HealthCare, Wuppertal, Germany

Werner Seeger

Affiliations University of Giessen and Marburg Lung Center, Giessen, Germany, Department of Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany

Hossein Ardeschir Ghofrani

Affiliation University of Giessen and Marburg Lung Center, Giessen, Germany

Ralph Theo Schermuly

ralph.schermuly@innere.med.uni-giessen.de

Affiliations University of Giessen and Marburg Lung Center, Giessen, Germany, Department of Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany

Competing Interests

JPS is employee of Bayer HealthCare, who also provided an unrestricted research grant. RTS declares he has been a consultant for Bayer Healthcare and has received speakers bureau (honoraria) from Bayer Healthcare. RTS also declares he has received grant/research support from Bayer HealthCare, Excellence Cluster Cardiopulmonary System, German Research Foundation, and the University of Giessen and Marburg Lung Center. HAG declares he has been a consultant for Bayer Healthcare and has received speakers bureau (honoraria) from Bayer Healthcare. HAG also declares he has received unrestricted research grant from Bayer Healthcare (related to this study), supports/grants Excellence Cluster Cardiopulmonary System, German Research Foundation, and the University of Giessen and Marburg Lung Center. FG declares he has been a consultant for Bayer Healthcare and has received grant/research support from Excellence Cluster Cardiopulmonary System, German Research Foundation, and the University of Giessen and Marburg Lung Center. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials, as detailed online in the guide for authors. ML, BK, NW and WS have declared that no competing interests exist.

ML, BK, NW and WS have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NW FG WS HAG RTS. Performed the experiments: ML BK XT AK. Analyzed the data: ML BK RTS. Contributed reagents/materials/analysis tools: AK JPS. Wrote the paper: ML BK RTS.