About the Authors

Kohei Hagiwara

Affiliations Division of Bio-system Pharmacology, Department of Pharmacology, Graduate School of Medicine, Osaka University, Osaka, Japan, School of Medicine, Osaka University, Osaka, Japan

Shushi Nagamori

Contributed equally to this work with: Shushi Nagamori, Yasuhiro M. Umemura

Affiliation Division of Bio-system Pharmacology, Department of Pharmacology, Graduate School of Medicine, Osaka University, Osaka, Japan

Yasuhiro M. Umemura

Contributed equally to this work with: Shushi Nagamori, Yasuhiro M. Umemura

Affiliation Division of Bio-system Pharmacology, Department of Pharmacology, Graduate School of Medicine, Osaka University, Osaka, Japan

Ryuichi Ohgaki

Affiliation Division of Bio-system Pharmacology, Department of Pharmacology, Graduate School of Medicine, Osaka University, Osaka, Japan

Hidekazu Tanaka

Affiliation Division of Bio-system Pharmacology, Department of Pharmacology, Graduate School of Medicine, Osaka University, Osaka, Japan

Daisuke Murata

Affiliations Graduate School of Systems Life Sciences, Kyushu University, Fukuoka, Japan, Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Saitama, Japan

Saya Nakagomi

Affiliation Division of Bio-system Pharmacology, Department of Pharmacology, Graduate School of Medicine, Osaka University, Osaka, Japan

Kazuko H. Nomura

Affiliations Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Saitama, Japan, Department of Biological Sciences, Faculty of Sciences, Kyushu University, Fukuoka, Japan

Eriko Kage-Nakadai

Affiliation Department of Physiology, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan

Shohei Mitani

Affiliation Department of Physiology, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan

Kazuya Nomura

Affiliations Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Saitama, Japan, Department of Biological Sciences, Faculty of Sciences, Kyushu University, Fukuoka, Japan

Yoshikatsu Kanai

ykanai@pharma1.med.osaka-u.ac.jp

Affiliations Division of Bio-system Pharmacology, Department of Pharmacology, Graduate School of Medicine, Osaka University, Osaka, Japan, Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Saitama, Japan

Competing Interests

The authors have read the journal’s policy and have the following conflicts: This study was partially supported by a commercial funder, Ajinomono, but this does not alter the authors’ adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: KH S. Nagamori YMU YK. Performed the experiments: KH YMU. Analyzed the data: KH S. Nagamori YMU RO HT DM KHN EKN SM KN YK. Contributed reagents/materials/analysis tools: KH YMU EKN SM DM S. Nakagomi KHN KN. Wrote the paper: KH YK.