About the Authors

Tzu-Pin Lu

Contributed equally to this work with: Tzu-Pin Lu, Chien-Yueh Lee

Affiliations YongLin Biomedical Engineering Center, National Taiwan University, Taipei, Taiwan, Bioinformatics and Biostatistics Core, Center of Genomic Medicine, National Taiwan University, Taipei, Taiwan

Chien-Yueh Lee

Contributed equally to this work with: Tzu-Pin Lu, Chien-Yueh Lee

Affiliation Graduate Institute of Biomedical Electronics and Bioinformatics and Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan

Mong-Hsun Tsai

Affiliations Bioinformatics and Biostatistics Core, Center of Genomic Medicine, National Taiwan University, Taipei, Taiwan, Institute of Biotechnology, National Taiwan University, Taipei, Taiwan

Yu-Chiao Chiu

Affiliation Graduate Institute of Biomedical Electronics and Bioinformatics and Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan

Chuhsing Kate Hsiao

Affiliations Bioinformatics and Biostatistics Core, Center of Genomic Medicine, National Taiwan University, Taipei, Taiwan, Department of Public Health, National Taiwan University, Taipei, Taiwan

Liang-Chuan Lai

llai@ntu.edu.tw (L-CL); chuangey@ntu.edu.tw (EYC)

Affiliations Bioinformatics and Biostatistics Core, Center of Genomic Medicine, National Taiwan University, Taipei, Taiwan, Graduate Institute of Physiology, National Taiwan University, Taipei, Taiwan

Eric Y. Chuang

llai@ntu.edu.tw (L-CL); chuangey@ntu.edu.tw (EYC)

Affiliations YongLin Biomedical Engineering Center, National Taiwan University, Taipei, Taiwan, Bioinformatics and Biostatistics Core, Center of Genomic Medicine, National Taiwan University, Taipei, Taiwan, Graduate Institute of Biomedical Electronics and Bioinformatics and Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan

Competing Interests

Eric Y. Chuang is a PLoS ONE Editorial Board member. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: TPL CKH EYC. Performed the experiments: TPL CYL YCC. Analyzed the data: TPL CYL YCC LCL. Contributed reagents/materials/analysis tools: MHT LCL. Wrote the paper: TPL CYL LCL EYC. Final approval of the manuscript: TPL CYL MHT YCC CKH LCL EYC.