About the Authors

Jhon Alberto Ochoa-Alvarez

Contributed equally to this work with: Jhon Alberto Ochoa-Alvarez, Harini Krishnan

Affiliations Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey, Stratford, New Jersey, United States of America, Department of Molecular Biology, School of Osteopathic Medicine, University of Medicine and Dentistry of New Jersey, Stratford, New Jersey, United States of America

Harini Krishnan

Contributed equally to this work with: Jhon Alberto Ochoa-Alvarez, Harini Krishnan

Affiliations Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey, Stratford, New Jersey, United States of America, Department of Molecular Biology, School of Osteopathic Medicine, University of Medicine and Dentistry of New Jersey, Stratford, New Jersey, United States of America

Yongquan Shen

Affiliation Department of Molecular Biology, School of Osteopathic Medicine, University of Medicine and Dentistry of New Jersey, Stratford, New Jersey, United States of America

Nimish K. Acharya

Affiliations Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey, Stratford, New Jersey, United States of America, New Jersey Institute for Successful Aging, University of Medicine and Dentistry of New Jersey, Stratford, New Jersey, United States of America

Min Han

Affiliations Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey, Stratford, New Jersey, United States of America, New Jersey Institute for Successful Aging, University of Medicine and Dentistry of New Jersey, Stratford, New Jersey, United States of America

Dean E. McNulty

Affiliation Proteomics and Biological Mass Spectrometry, Molecular Discovery Research, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America

Hitoki Hasegawa

Affiliation Division of Cancer Biology, School of Medicine, Nagoya University, Nagoya, Japan

Toshinori Hyodo

Affiliation Division of Cancer Biology, School of Medicine, Nagoya University, Nagoya, Japan

Takeshi Senga

Affiliation Division of Cancer Biology, School of Medicine, Nagoya University, Nagoya, Japan

Jian-Guo Geng

Affiliation Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, Michigan, United States of America

Mary Kosciuk

Affiliation New Jersey Institute for Successful Aging, University of Medicine and Dentistry of New Jersey, Stratford, New Jersey, United States of America

Seung S. Shin

Affiliation Department of Surgery, Cancer Institute of New Jersey, New Brunswick, New Jersey, United States of America

James S. Goydos

Affiliation Department of Surgery, Cancer Institute of New Jersey, New Brunswick, New Jersey, United States of America

Dmitry Temiakov

Affiliations Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey, Stratford, New Jersey, United States of America, Department of Cell Biology, University of Medicine and Dentistry of New Jersey, Stratford, New Jersey, United States of America

Robert G. Nagele

Affiliations Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey, Stratford, New Jersey, United States of America, New Jersey Institute for Successful Aging, University of Medicine and Dentistry of New Jersey, Stratford, New Jersey, United States of America

Gary S. Goldberg

gary.goldberg@umdnj.edu

Affiliations Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey, Stratford, New Jersey, United States of America, Department of Molecular Biology, School of Osteopathic Medicine, University of Medicine and Dentistry of New Jersey, Stratford, New Jersey, United States of America

Competing Interests

Dr. Goldberg and Dr. Temiakov are scientific advisors and shareholders of Sentrimed, which has funded part of this work and supplied the reagent MASL. Dr. McNulty is an employee of GlaxoSmithKline. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: GSG YS DT RGN SSS JSG. Performed the experiments: JAO-A HK YS NKA MH DEM HH TH TS J-GG MK DT RGN GSG SSS. Analyzed the data: JAO-A HK YS MH DEM TS J-GG DT RGN GSG. Contributed reagents/materials/analysis tools: J-GG JSG. Wrote the paper: GSG HK JAO-A.