About the Authors

Takuya Yagi

Affiliation Department of Neurology, School of Medicine, Keio University, Tokyo, Japan

Arifumi Kosakai

Affiliation Department of Neurology, School of Medicine, Keio University, Tokyo, Japan

Daisuke Ito

d-ito@jk9.so-net.ne.jp

Affiliation Department of Neurology, School of Medicine, Keio University, Tokyo, Japan

Yohei Okada

Affiliations Department of Physiology, School of Medicine, Keio University, Tokyo, Japan, Kanrinmaru Project, School of Medicine, Keio University, Tokyo, Japan

Wado Akamatsu

Affiliation Department of Physiology, School of Medicine, Keio University, Tokyo, Japan

Yoshihiro Nihei

Affiliation Department of Neurology, School of Medicine, Keio University, Tokyo, Japan

Akira Nabetani

Affiliation Laboratory of Cell Cycle Regulation, Department of Gene Mechanisms, Graduate School of Biostudies, Kyoto University, Kyoto, Japan

Fuyuki Ishikawa

Affiliation Laboratory of Cell Cycle Regulation, Department of Gene Mechanisms, Graduate School of Biostudies, Kyoto University, Kyoto, Japan

Yasumichi Arai

Affiliation Division of Geriatric Medicine, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan

Nobuyoshi Hirose

Affiliation Division of Geriatric Medicine, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan

Hideyuki Okano

Affiliation Department of Physiology, School of Medicine, Keio University, Tokyo, Japan

Norihiro Suzuki

Affiliation Department of Neurology, School of Medicine, Keio University, Tokyo, Japan

Competing Interests

The authors declare that they received grants from Eisai Co. Ltd for this study. There are no other relevant declarations relating to employment, consultancy, patents, products in development or marketed products. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: DI. Performed the experiments: TY AK AN YO WA YN. Analyzed the data: FI YA NH HO NS. Wrote the paper: TY DI HO NS.