Delivery of Platelet-Derived Growth Factor as a Chemotactic Factor for Mesenchymal Stem Cells by Bone-Mimetic Electrospun Scaffolds

Matthew C. Phipps; Yuanyuan Xu; Susan L. Bellis

doi:10.1371/journal.pone.0040831

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Open Access

Peer-reviewed

Research Article

Delivery of Platelet-Derived Growth Factor as a Chemotactic Factor for Mesenchymal Stem Cells by Bone-Mimetic Electrospun Scaffolds

Matthew C. Phipps,

Affiliation Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Yuanyuan Xu,

Affiliation Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Susan L. Bellis

* E-mail: bellis@uab.edu

Affiliations Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯

Delivery of Platelet-Derived Growth Factor as a Chemotactic Factor for Mesenchymal Stem Cells by Bone-Mimetic Electrospun Scaffolds

Matthew C. Phipps,
Yuanyuan Xu,
Susan L. Bellis

Published: July 12, 2012
https://doi.org/10.1371/journal.pone.0040831

About the Authors

Matthew C. Phipps

Affiliation Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

Yuanyuan Xu

Affiliation Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

Susan L. Bellis

* E-mail: bellis@uab.edu

Affiliations Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YX MCP SLB. Performed the experiments: YX MCP. Analyzed the data: MCP YX SLB. Contributed reagents/materials/analysis tools: YX MCP SB. Wrote the paper: MCP YX SLB.

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Chemotaxis
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Mesenchymal stem cells
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Collagens
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Chemokines
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Cell migration
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Adsorption
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Chemotaxis assay
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Growth factors
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