About the Authors

Juan Manuel Ortiz-Sanchez

juanma@ucsd.edu (JMO-S); bjgrant@umich.edu (BJG)

Affiliation Department of Chemistry and Biochemistry and Center for Theoretical Biological Physics, University of California San Diego, La Jolla, California, United States of America

Sara E. Nichols

Affiliations Department of Chemistry and Biochemistry and Center for Theoretical Biological Physics, University of California San Diego, La Jolla, California, United States of America, Department of Pharmacology, University of California San Diego, La Jolla, California, United States of America

Jacqueline Sayyah

Affiliation Department of Pharmacology, University of California San Diego, La Jolla, California, United States of America

Joan Heller Brown

Affiliation Department of Pharmacology, University of California San Diego, La Jolla, California, United States of America

J. Andrew McCammon

Affiliations Department of Chemistry and Biochemistry and Center for Theoretical Biological Physics, University of California San Diego, La Jolla, California, United States of America, Department of Pharmacology, University of California San Diego, La Jolla, California, United States of America, Howard Hughes Medical Institute, University of California San Diego, La Jolla, California, United States of America

Barry J. Grant

juanma@ucsd.edu (JMO-S); bjgrant@umich.edu (BJG)

Affiliation Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JMO BJG JAM. Performed the experiments: JMO BJG JS. Analyzed the data: JMO SEN BJG JS. Contributed reagents/materials/analysis tools: JMO BJG JS. Wrote the paper: JMO SEN BJG JAM JS JHB.