About the Authors

Ming Liu

Contributed equally to this work with: Ming Liu, Shuang Wang

Affiliations Beijing Institute of Biotechnology, Beijing, China, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China, Genor Biopharma Co., Ltd, Shanghai, China

Shuang Wang

Contributed equally to this work with: Ming Liu, Shuang Wang

Affiliation Beijing Institute of Biotechnology, Beijing, China

Tingguang Sun

Affiliation Department of Biological and Chemical Engineering, Guangxi University of Technology, Liuzhou, China

Jiguo Su

Affiliation College of Science, Yanshan University, Qinhuangdao, China

Yuanxing Zhang

szwyhhh@yahoo.com.cn (ZS) (YZ); yue_junjie@126.com (JY) (JY); yxzhang@ecust.edu.cn (YZ) (ZS)

Affiliation State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China

Junjie Yue

szwyhhh@yahoo.com.cn (ZS) (YZ); yue_junjie@126.com (JY) (JY); yxzhang@ecust.edu.cn (YZ) (ZS)

Affiliation Beijing Institute of Biotechnology, Beijing, China

Zhiwei Sun

szwyhhh@yahoo.com.cn (ZS) (YZ); yue_junjie@126.com (JY) (JY); yxzhang@ecust.edu.cn (YZ) (ZS)

Affiliation Beijing Institute of Biotechnology, Beijing, China

Competing Interests

Although the first author Ming Liu is employed by the Genor Biopharma Co., this does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: ML YXZ JJY ZWS. Performed the experiments: ML SW. Analyzed the data: ML TGS JGS. Contributed reagents/materials/analysis tools: ML JGS. Wrote the paper: ML SW.