About the Authors

Stefano Piana

Contributed equally to this work with: Stefano Piana, Kresten Lindorff-Larsen, Robert M. Dirks

Stefano.Piana-Agostinetti@DEShawResearch.com (SP); Kresten.Lindorff-Larsen@DEShawResearch.com (KL-L); David.Shaw@DEShawResearch.com (DES)

Affiliation D. E. Shaw Research, New York, New York, United States of America

Kresten Lindorff-Larsen

Contributed equally to this work with: Stefano Piana, Kresten Lindorff-Larsen, Robert M. Dirks

Stefano.Piana-Agostinetti@DEShawResearch.com (SP); Kresten.Lindorff-Larsen@DEShawResearch.com (KL-L); David.Shaw@DEShawResearch.com (DES)

Affiliation D. E. Shaw Research, New York, New York, United States of America

Robert M. Dirks

Contributed equally to this work with: Stefano Piana, Kresten Lindorff-Larsen, Robert M. Dirks

Affiliation D. E. Shaw Research, New York, New York, United States of America

John K. Salmon

Affiliation D. E. Shaw Research, New York, New York, United States of America

Ron O. Dror

Affiliation D. E. Shaw Research, New York, New York, United States of America

David E. Shaw

Stefano.Piana-Agostinetti@DEShawResearch.com (SP); Kresten.Lindorff-Larsen@DEShawResearch.com (KL-L); David.Shaw@DEShawResearch.com (DES)

Affiliations D. E. Shaw Research, New York, New York, United States of America, Center for Computational Biology and Bioinformatics, Columbia University, New York, New York, United States of America

Competing Interests

All the authors are affiliated with D. E. Shaw Research, the funder of this study. This research was conducted within D. E. Shaw Research, of which DES is the sole beneficial owner and Chief Scientist. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SP KL-L RMD DES. Performed the experiments: SP KL-L RMD. Analyzed the data: SP KL-L RMD. Contributed reagents/materials/analysis tools: JKS. Wrote the paper: SP KL-L RMD ROD DES.