About the Authors

Wenxue Ma

Affiliation Department of Medicine, Stem Cell Program and Moores Cancer Center, University of California San Diego, La Jolla, California, United States of America

Alejandro Gutierrez

Affiliation Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children’s Hospital Boston, Boston, Massachusetts, United States of America

Daniel J. Goff

Affiliation Department of Medicine, Stem Cell Program and Moores Cancer Center, University of California San Diego, La Jolla, California, United States of America

Ifat Geron

Affiliation Department of Medicine, Stem Cell Program and Moores Cancer Center, University of California San Diego, La Jolla, California, United States of America

Anil Sadarangani

Affiliation Department of Medicine, Stem Cell Program and Moores Cancer Center, University of California San Diego, La Jolla, California, United States of America

Christina A. M. Jamieson

Affiliation Department of Medicine, Stem Cell Program and Moores Cancer Center, University of California San Diego, La Jolla, California, United States of America

Angela C. Court

Affiliation Department of Medicine, Stem Cell Program and Moores Cancer Center, University of California San Diego, La Jolla, California, United States of America

Alice Y. Shih

Affiliation Department of Medicine, Stem Cell Program and Moores Cancer Center, University of California San Diego, La Jolla, California, United States of America

Qingfei Jiang

Affiliation Department of Medicine, Stem Cell Program and Moores Cancer Center, University of California San Diego, La Jolla, California, United States of America

Christina C. Wu

Affiliation Department of Medicine, Stem Cell Program and Moores Cancer Center, University of California San Diego, La Jolla, California, United States of America

Kang Li

Affiliation Oncology Research Unit, Pfizer Global Research and Development, La Jolla Laboratories, San Diego, California, United States of America

Kristen M. Smith

Affiliation Department of Medicine, Stem Cell Program and Moores Cancer Center, University of California San Diego, La Jolla, California, United States of America

Leslie A. Crews

Affiliation Department of Medicine, Stem Cell Program and Moores Cancer Center, University of California San Diego, La Jolla, California, United States of America

Neil W. Gibson

Affiliation Oncology Research Unit, Pfizer Global Research and Development, La Jolla Laboratories, San Diego, California, United States of America

Ida Deichaite

Affiliation Department of Medicine, Stem Cell Program and Moores Cancer Center, University of California San Diego, La Jolla, California, United States of America

Sheldon R. Morris

Affiliation Department of Medicine, Stem Cell Program and Moores Cancer Center, University of California San Diego, La Jolla, California, United States of America

Ping Wei

Affiliation Oncology Research Unit, Pfizer Global Research and Development, La Jolla Laboratories, San Diego, California, United States of America

Dennis A. Carson

Affiliation Department of Medicine, Stem Cell Program and Moores Cancer Center, University of California San Diego, La Jolla, California, United States of America

A. Thomas Look

Affiliation Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children’s Hospital Boston, Boston, Massachusetts, United States of America

Catriona H. M. Jamieson

cjamieson@ucsd.edu

Affiliation Department of Medicine, Stem Cell Program and Moores Cancer Center, University of California San Diego, La Jolla, California, United States of America

Competing Interests

A portion of this research study was funded by a sponsored research agreement with Pfizer (Pfizer/28-1076), and the antibody utilized in this study was provided by Pfizer. K. Li and N. Gibson were employees of Pfizer while engaged in the research project. P. Wei is an employee of Pfizer and owns stock in the company. This does not alter the authors’ adherence to all the PLoS ONE policies on sharing data and materials. Authors W. Ma, D.J. Goff, I. Geron, A. Sadarangani, C.A.M. Jamieson, A. Court, A. Shih, Q. Jiang, C. Wu, K. Smith, L.A. Crews, I. Deichaite, S. Morris, and D. Carson declare no potential conflicts of interest.

Author Contributions

Conceived and designed the experiments: WM DAC ATL CHMJ. Performed the experiments: WM AG DJG IG AS CAMJ ACC AYS QJ CCW KMS PW. Analyzed the data: WM CAMJ KMS LAC SRM ATL DAC CHMJ. Contributed reagents/materials/analysis tools: KL PW NWG. Wrote the paper: WM LAC DAC ATL CHMJ. Obtained permission for use of the Pfizer antibody: ID. Accept direct responsibility for the manuscript: WM CHJM.