Glutamate Induces Mitochondrial Dynamic Imbalance and Autophagy Activation: Preventive Effects of Selenium

Santosh Kumari; Suresh L. Mehta; P. Andy Li

doi:10.1371/journal.pone.0039382

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Open Access

Peer-reviewed

Research Article

Glutamate Induces Mitochondrial Dynamic Imbalance and Autophagy Activation: Preventive Effects of Selenium

Santosh Kumari ,

Contributed equally to this work with: Santosh Kumari, Suresh L. Mehta

Affiliation Department of Pharmaceutical Sciences, Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, North Carolina, United States of America
⨯
Suresh L. Mehta ,

Contributed equally to this work with: Santosh Kumari, Suresh L. Mehta

Affiliation Department of Pharmaceutical Sciences, Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, North Carolina, United States of America
⨯
P. Andy Li

* E-mail: pli@nccu.edu

Affiliation Department of Pharmaceutical Sciences, Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, North Carolina, United States of America
⨯

Glutamate Induces Mitochondrial Dynamic Imbalance and Autophagy Activation: Preventive Effects of Selenium

Santosh Kumari,
Suresh L. Mehta,
P. Andy Li

Published: June 19, 2012
https://doi.org/10.1371/journal.pone.0039382

About the Authors

Santosh Kumari

Contributed equally to this work with: Santosh Kumari, Suresh L. Mehta

Affiliation Department of Pharmaceutical Sciences, Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, North Carolina, United States of America

Suresh L. Mehta

Contributed equally to this work with: Santosh Kumari, Suresh L. Mehta

Affiliation Department of Pharmaceutical Sciences, Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, North Carolina, United States of America

P. Andy Li

* E-mail: pli@nccu.edu

Affiliation Department of Pharmaceutical Sciences, Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, North Carolina, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SK SLM PAL. Performed the experiments: SK SLM. Analyzed the data: SK SLM PAL. Contributed reagents/materials/analysis tools: SK SLM PAL. Wrote the paper: SK SLM PAL.

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Glutamate
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Mitochondria
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Selenium
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Autophagic cell death
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Membrane potential
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Mitochondrial membrane
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Oxygen consumption
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Toxicity
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