Lipopolysaccharides Impair Insulin Gene Expression in Isolated Islets of Langerhans via Toll-Like Receptor-4 and NF-κB Signalling

Julie Amyot; Meriem Semache; Mourad Ferdaoussi; Ghislaine Fontés; Vincent Poitout

doi:10.1371/journal.pone.0036200

Loading metrics

Open Access

Peer-reviewed

Research Article

Lipopolysaccharides Impair Insulin Gene Expression in Isolated Islets of Langerhans via Toll-Like Receptor-4 and NF-κB Signalling

Julie Amyot,

Affiliations Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Quebec, Canada, Department of Biochemistry, Université de Montréal, Montréal, Quebec, Canada
⨯
Meriem Semache,

Affiliations Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Quebec, Canada, Department of Biochemistry, Université de Montréal, Montréal, Quebec, Canada
⨯
Mourad Ferdaoussi,

Affiliation Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Quebec, Canada
⨯
Ghislaine Fontés,

Affiliation Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Quebec, Canada
⨯
Vincent Poitout

* E-mail: vincent.poitout@umontreal.ca

Affiliations Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Quebec, Canada, Department of Biochemistry, Université de Montréal, Montréal, Quebec, Canada, Department of Medicine, Université de Montréal, Montréal, Quebec, Canada
⨯

Lipopolysaccharides Impair Insulin Gene Expression in Isolated Islets of Langerhans via Toll-Like Receptor-4 and NF-κB Signalling

Julie Amyot,
Meriem Semache,
Mourad Ferdaoussi,
Ghislaine Fontés,
Vincent Poitout

Published: April 27, 2012
https://doi.org/10.1371/journal.pone.0036200

About the Authors

Julie Amyot

Affiliations Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Quebec, Canada, Department of Biochemistry, Université de Montréal, Montréal, Quebec, Canada

Meriem Semache

Mourad Ferdaoussi

Affiliation Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Quebec, Canada

Ghislaine Fontés

Affiliation Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Quebec, Canada

Vincent Poitout

* E-mail: vincent.poitout@umontreal.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JA MF VP. Performed the experiments: JA MS GF. Analyzed the data: JA VP. Wrote the paper: JA VP.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Insulin
Is the Subject Area "Insulin" applicable to this article?

Thanks for your feedback.
Transcription factors
Is the Subject Area "Transcription factors" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Glucose
Is the Subject Area "Glucose" applicable to this article?

Thanks for your feedback.
Insulin secretion
Is the Subject Area "Insulin secretion" applicable to this article?

Thanks for your feedback.
Immune receptor signaling
Is the Subject Area "Immune receptor signaling" applicable to this article?

Thanks for your feedback.
Insulin signaling
Is the Subject Area "Insulin signaling" applicable to this article?

Thanks for your feedback.
Toll-like receptors
Is the Subject Area "Toll-like receptors" applicable to this article?

Thanks for your feedback.