About the Authors

Michael Erb

Affiliation Santhera Pharmaceuticals, Liestal, Switzerland

Barbara Hoffmann-Enger

Affiliation Santhera Pharmaceuticals, Liestal, Switzerland

Holger Deppe

Affiliation Santhera Pharmaceuticals, Liestal, Switzerland

Michael Soeberdt

Affiliation Santhera Pharmaceuticals, Liestal, Switzerland

Roman H. Haefeli

Affiliations Santhera Pharmaceuticals, Liestal, Switzerland, Biozentrum, University of Basel, Basel, Switzerland

Christian Rummey

Affiliation Santhera Pharmaceuticals, Liestal, Switzerland

Achim Feurer

Affiliation Santhera Pharmaceuticals, Liestal, Switzerland

Nuri Gueven

nuri.gueven@santhera.com

Affiliation Santhera Pharmaceuticals, Liestal, Switzerland

Competing Interests

The authors have read the journal's policy and have the following conflicts: During the preparation of this manuscript, all authors were paid employees of Santhera Pharmaceuticals (Switzerland). Santhera is marketing Catena® (Idebenone) for the treatment of Friedreich's Ataxia in Canada and develops Catena for several other mitochondrial and neuromuscular indications. Compounds # 1, 3–5, 7, 9–14, 16–35, 53–57, 60–71 are subject of two international patent applications (WO/2012/022467 and WO/2012/022468). This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: ME NG. Performed the experiments: ME RHH. Analyzed the data: ME CR NG. Contributed reagents/materials/analysis tools: BH HD MS AF. Wrote the paper: AF NG. Contributed reagents, designed and synthesized compounds: BH HD MS AF.