About the Authors

Claudia Nicolaije

Contributed equally to this work with: Claudia Nicolaije, Karin E. M. Diderich

Affiliation Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands

Karin E. M. Diderich

Contributed equally to this work with: Claudia Nicolaije, Karin E. M. Diderich

Affiliation MGC Department of Cell Biology & Genetics, Center for Biomedical Genetics, Erasmus MC, Rotterdam, The Netherlands

S. M. Botter

Affiliation MGC Department of Cell Biology & Genetics, Center for Biomedical Genetics, Erasmus MC, Rotterdam, The Netherlands

Matthias Priemel

Affiliation Department of Trauma, Hand, and Reconstructive Surgery, School of Medicine, Hamburg University, Hamburg, Germany

Jan H. Waarsing

Affiliation Department of Orthopedics, Erasmus MC, Rotterdam, The Netherlands

Judd S. Day

Affiliation Department of Orthopedics, Erasmus MC, Rotterdam, The Netherlands

Renata M. C. Brandt

Affiliation MGC Department of Cell Biology & Genetics, Center for Biomedical Genetics, Erasmus MC, Rotterdam, The Netherlands

Arndt F. Schilling

Affiliation Department of Trauma, Hand, and Reconstructive Surgery, School of Medicine, Hamburg University, Hamburg, Germany

Harrie Weinans

Affiliation Department of Orthopedics, Erasmus MC, Rotterdam, The Netherlands

Bram C. Van der Eerden

Affiliation Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands

Gijsbertus T. J. van der Horst

Affiliation MGC Department of Cell Biology & Genetics, Center for Biomedical Genetics, Erasmus MC, Rotterdam, The Netherlands

Jan H. J. Hoeijmakers

Affiliation MGC Department of Cell Biology & Genetics, Center for Biomedical Genetics, Erasmus MC, Rotterdam, The Netherlands

Johannes P. T. M. van Leeuwen

j.vanleeuwen@erasmusmc.nl

Affiliation Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands

Competing Interests

Dr. Hoeijmakers is non-executive CSO of DNage, but no financial support was obtained. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials. All other authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CN KD JVL JH GVH HW. Performed the experiments: CN KD SB RB MP AS JW BVE JD. Analyzed the data: CN KD SB JW MP AS JVL. Contributed reagents/materials/analysis tools: JW HW JH BVE. Wrote the paper: CN KD JVL.