About the Authors

Ashwin Patkar

Affiliation Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, United States of America

William Gilmer

Affiliation Department of Psychiatry, Northwestern University, School of Medicine, Chicago, Illinois, United States of America

Chi-un Pae

Affiliation Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, United States of America

Paul A. Vöhringer

Affiliations Mood Disorders Program, Department of Psychiatry, Tufts Medical Center, Boston, Massachusetts, United States of America, Hospital Clinico, Facultad de Medicina, Universidad Chile, Santiago, Chile, Graduate Program, Clinical and Translational Science Institute, Sackler School of Graduate and Biomedical Sciences, Tufts University, Boston, Massachusetts, United States of America

Michael Ziffra

Affiliation Department of Psychiatry, Northwestern University, School of Medicine, Chicago, Illinois, United States of America

Edward Pirok

Affiliation Department of Psychiatry, Northwestern University, School of Medicine, Chicago, Illinois, United States of America

Molly Mulligan

Affiliation Department of Psychiatry, Northwestern University, School of Medicine, Chicago, Illinois, United States of America

Megan M. Filkowski

Affiliation Department of Psychiatry, Emory University School of Medicine, Atlanta, Georgia, United States of America

Elizabeth A. Whitham

Affiliation Mood Disorders Program, Department of Psychiatry, Tufts Medical Center, Boston, Massachusetts, United States of America

Niki S. Holtzman

Affiliation Mood Disorders Program, Department of Psychiatry, Tufts Medical Center, Boston, Massachusetts, United States of America

Sairah B. Thommi

Affiliation Mood Disorders Program, Department of Psychiatry, Tufts Medical Center, Boston, Massachusetts, United States of America

Tanya Logvinenko

Affiliation Biostatistics Research Center at the Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts, United States of America

Antony Loebel

Affiliation Sunovion Pharmaceuticals, Fort Lee, New Jersey, United States of America

Prakash Masand

Affiliation Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, United States of America

S. Nassir Ghaemi

nghaemi@tuftsmedicalcenter.org

Affiliations Mood Disorders Program, Department of Psychiatry, Tufts Medical Center, Boston, Massachusetts, United States of America, Tufts University School of Medicine, Boston, Massachusetts, United States of America

Competing Interests

Dr. Ashwin Patkar is a Consultant for Bristol-Myers Squibb, GlaxoSmithKline, and Reckitt Benckiser; he is on the Speaker’s Bureau and received honoraria from Bristol-Myers Squibb, Cephalon/Alkermes, Pfizer, and Reckitt Benckiser; and has received Grant Support from National Institutes of Health (NIDA, NIAAA), SAMHSA, AstraZeneca, Bristol-Myers Squibb, Cephalon, Forest, GlaxoSmithKline, Janssen, Jazz Pharmaceuticals, Lundbeck, McNeil Consumer & Specialty Inc, Organon, Pfizer and Shire Pharmaceuticals. Dr. Prakash Masand is a consultant for Eli Lilly and Company, Pamlabs, Pfizer Inc., Sanofi-Aventis, and Schering Plough; he is on the Speaker’s Bureau for Eli Lilly and Company, Grey Healthcare, Forest Pharmaceuticals, GlaxoSmithKline, Insight Medical Communicatiions, Janssen Cilag, and Pfizer Inc.; he also has stock ownership with Orexigen Therapeutics and Titan Pharmaceuticals. Dr. William Gilmer has received honoraria and a research grant from Pfizer, and served on their Speaker's Bureau. Dr. Ghaemi has received research grants from Pfizer and Sunovion and has provided research consultations for Pfizer and Sunovion. Dr. Chi-un Pae has served as a consultant for GlaxoSmithKline, Otsuka Korea Pharmaceuticals, Ltd., Eli Lilly and Company, AstraZeneca, Wyeth Korea; has served on the Speaker’s Bureau for Sanofi-Aventis, Schering Plough, Eli Lilly and Company, GlaxoSmithKline, AstraZeneca, Lundbeck Korea, WhanIn Pharmaceuticals, Otsuka Korea Pharmaceuticals, and Wyeth Korea; and has received grants from the Ministry for Health, Welfare and Family Affairs, KISTEP, Catholic Medical Center, The Catholic University of Korea College of Medicine Alumni, Eli Lilly and Company, GlaxoSmithKline, Otsuka Korea Pharmaceuticals, and AstraZeneca. Dr Antony Loebel is currently Executive Vice President for Clinical Research at Sunovion Pharmaceuticals. He was employed by Pfizer at the time the study was conducted. Drs. Michael Ziffra, Edward Pirok, Paul Vohringer, Molly Mulligan, Tanya Logvinenko, and Ms. Megan Filkowski, Elizabeth Whitham, Sairah Thommi, and Niki Holtzman have no conflicts to disclose. The above-stated relationships do not alter the authors’ adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: WG PM AL SNG AP. Performed the experiments: WG MZ CP MMF SNG EAW SBT AP MM EP. Analyzed the data: PM SNG EAW SBT NH PV TL. Contributed reagents/materials/analysis tools: SNG TL. Wrote the paper: PM SNG SBT EAW AP NH TL PV.