About the Authors

Li Wang

Contributed equally to this work with: Li Wang, Daniel G. Hurley

Affiliation Department of Molecular Medicine and Pathology, School of Medical Sciences, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand

Daniel G. Hurley

Contributed equally to this work with: Li Wang, Daniel G. Hurley

Affiliations Department of Molecular Medicine and Pathology, School of Medical Sciences, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand, Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand

Wendy Watkins

Affiliation Department of Molecular Medicine and Pathology, School of Medical Sciences, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand

Hiromitsu Araki

Affiliations Department of Molecular Medicine and Pathology, School of Medical Sciences, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand, GNI Ltd, Shinjuku-ku, Tokyo, Japan

Yoshinori Tamada

Affiliations Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan, GNI Ltd, Shinjuku-ku, Tokyo, Japan

Anita Muthukaruppan

Affiliation Department of Molecular Medicine and Pathology, School of Medical Sciences, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand

Louis Ranjard

Affiliation Bioinformatics Institute, University of Auckland, Auckland, New Zealand

Eliane Derkac

Affiliation Bioinformatics Institute, University of Auckland, Auckland, New Zealand

Seiya Imoto

Affiliation Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan

Satoru Miyano

Affiliation Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan

Edmund J. Crampin

Affiliations Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand, Department of Engineering Science, University of Auckland, Auckland, New Zealand

Cristin G. Print

c.print@auckland.ac.nz

Affiliations Department of Molecular Medicine and Pathology, School of Medical Sciences, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand, Bioinformatics Institute, University of Auckland, Auckland, New Zealand

Competing Interests

HA and YT are past employees of GNI Ltd., a Japanese biotechnology company that provided a subset of the siRNA reagents used in this study. HA, YT, SI, SM, and CGP have held/hold stock in GNI Ltd. None of the authors are current employees of GNI Ltd. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: LW DGH EJC CGP. Performed the experiments: LW DGH AM. Analyzed the data: WW HA YT LR ED SI SM EJC CGP. Contributed reagents/materials/analysis tools: DGH YT SI SM. Wrote the paper: LW CGP.