About the Authors

Zuyi Weng

Contributed equally to this work with: Zuyi Weng, Bodi Zhang

Affiliations Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Boston, Massachusetts, United States of America, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts, United States of America

Bodi Zhang

Contributed equally to this work with: Zuyi Weng, Bodi Zhang

Affiliations Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Boston, Massachusetts, United States of America, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts, United States of America, Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts, United States of America

Shahrzad Asadi

Affiliations Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Boston, Massachusetts, United States of America, Department of Pharmacy, Tufts Medical Center, Boston, Massachusetts, United States of America

Nikolaos Sismanopoulos

Affiliation Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Boston, Massachusetts, United States of America

Alan Butcher

Affiliation Thorne Research, Inc., Sandpoint, Idaho, United States of America

Xueyan Fu

Affiliation Vitamin K Lab, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, United States of America

Alexandra Katsarou-Katsari

Affiliation First Department of Dermatology, A. Sygros Hospital, Athens University Medical School, Athens, Greece

Christina Antoniou

Affiliation First Department of Dermatology, A. Sygros Hospital, Athens University Medical School, Athens, Greece

Theoharis C. Theoharides

theoharis.theoharides@tufts.edu

Affiliations Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Boston, Massachusetts, United States of America, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts, United States of America, Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts, United States of America, Department of Internal Medicine, Tufts University School of Medicine and Tufts Medical Center, Boston, Massachusetts, United States of America

Competing Interests

Dr. Alan Butcher is the Director of Operations for Thorne Research Inc. that provided the water-soluble quercetin. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: TCT ZW BZ. Performed the experiments: ZW BZ SA NS XF AK-K CA. Analyzed the data: TCT ZW BZ AK-K CA. Contributed reagents/materials/analysis tools: AB AK-K CA. Wrote the paper: TCT ZW BZ.