About the Authors

Giske Biesbroek

Affiliation Department of Pediatric Infectious Diseases and Immunity UMC Utrecht, Utrecht, The Netherlands

Elisabeth A. M. Sanders

Affiliation Department of Pediatric Infectious Diseases and Immunity UMC Utrecht, Utrecht, The Netherlands

Guus Roeselers

Affiliation Research Group Microbiology and Systems Biology, TNO Earth, Environmental and Life Sciences, Zeist, The Netherlands

Xinhui Wang

Affiliation Department of Pediatric Infectious Diseases and Immunity UMC Utrecht, Utrecht, The Netherlands

Martien P. M. Caspers

Affiliation Research Group Microbiology and Systems Biology, TNO Earth, Environmental and Life Sciences, Zeist, The Netherlands

Krzysztof Trzciński

Affiliation Department of Pediatric Infectious Diseases and Immunity UMC Utrecht, Utrecht, The Netherlands

Debby Bogaert

Contributed equally to this work with: Debby Bogaert, Bart J. F. Keijser

dbogaert@umcutrecht.nl

Affiliation Department of Pediatric Infectious Diseases and Immunity UMC Utrecht, Utrecht, The Netherlands

Bart J. F. Keijser

Contributed equally to this work with: Debby Bogaert, Bart J. F. Keijser

Affiliation Research Group Microbiology and Systems Biology, TNO Earth, Environmental and Life Sciences, Zeist, The Netherlands

Competing Interests

GR, MC and BK are employees of TNO Earth, Environmental and Life Sciences, Zeist. DB and KT reported receiving consulting fees from Pfizer. ES reports receiving unrestricted grants from Pfizer and Baxter for research, consulting fees for Pfizer and GlaxoSmithKline, lecturing fees from Pfizer and grant support from Pfizer and GlaxoSmithKline for vaccine studies. These grants were not received for the research described in this paper. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials. For all other authors, no potential conflicts reported.

Author Contributions

Conceived and designed the experiments: GB BK DB ES KT. Performed the experiments: GB BK. Analyzed the data: GB BK DB GR MC XW. Contributed reagents/materials/analysis tools: DB BK. Wrote the paper: GB DB ES BK.