About the Authors

Suzhen Dong

Contributed equally to this work with: Suzhen Dong, Qingwen Zeng, Yale Duan, Chunxia Li

Affiliations Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai, Key Laboratory of Brain Functional Genomics, East China Normal University, Shanghai, China, Institutes for Advanced Interdisciplinary Research, East China Normal University, Shanghai, China

Qingwen Zeng

Contributed equally to this work with: Suzhen Dong, Qingwen Zeng, Yale Duan, Chunxia Li

Affiliation Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai, Key Laboratory of Brain Functional Genomics, East China Normal University, Shanghai, China

E. Siobhan Mitchell

Affiliation Unilever R&D, Vlaardingen, The Netherlands

Jin Xiu

Affiliation Unilever R&D, Shanghai, China

Yale Duan

Contributed equally to this work with: Suzhen Dong, Qingwen Zeng, Yale Duan, Chunxia Li

Affiliation Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai, Key Laboratory of Brain Functional Genomics, East China Normal University, Shanghai, China

Chunxia Li

Contributed equally to this work with: Suzhen Dong, Qingwen Zeng, Yale Duan, Chunxia Li

Affiliation Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai, Key Laboratory of Brain Functional Genomics, East China Normal University, Shanghai, China

Jyoti K. Tiwari

Affiliation Unilever R&D, Bangalore, India

Yinghe Hu

Affiliations Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai, Key Laboratory of Brain Functional Genomics, East China Normal University, Shanghai, China, Institutes for Advanced Interdisciplinary Research, East China Normal University, Shanghai, China

Xiaohua Cao

zzhao@brain.ecnu.edu.cn (ZZ); xhcao@brain.ecnu.edu.cn (XC)

Affiliation Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai, Key Laboratory of Brain Functional Genomics, East China Normal University, Shanghai, China

Zheng Zhao

zzhao@brain.ecnu.edu.cn (ZZ); xhcao@brain.ecnu.edu.cn (XC)

Affiliation Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai, Key Laboratory of Brain Functional Genomics, East China Normal University, Shanghai, China

Competing Interests

ESM, JX and JKT are employees of Unilever R&D, the research arm of a food company which does sell products with very small amounts of curcumin. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: YH XC ZZ ESM JKT JX. Performed the experiments: SD QZ YD CL. Analyzed the data: XC ZZ. Contributed reagents/materials/analysis tools: XC ZZ. Wrote the paper: XC ZZ YH ESM. Obtained permission for use of Laboratory animal facility: XC.