About the Authors

Lily Alvarez-Jaimes

Affiliation Janssen Pharmaceutical Companies of Johnson & Johnson, San Diego, California, United States of America

Steven W. Sutton

ssutton@its.jnj.com

Affiliation Janssen Pharmaceutical Companies of Johnson & Johnson, San Diego, California, United States of America

Diane Nepomuceno

Affiliation Janssen Pharmaceutical Companies of Johnson & Johnson, San Diego, California, United States of America

S. Timothy Motley

Affiliation Janssen Pharmaceutical Companies of Johnson & Johnson, San Diego, California, United States of America

Miroslav Cik

Affiliation Janssen Pharmaceutical Companies of Johnson & Johnson, San Diego, California, United States of America

Emily Stocking

Affiliation Janssen Pharmaceutical Companies of Johnson & Johnson, San Diego, California, United States of America

James Shoblock

Affiliation Janssen Pharmaceutical Companies of Johnson & Johnson, San Diego, California, United States of America

Pascal Bonaventure

Affiliation Janssen Pharmaceutical Companies of Johnson & Johnson, San Diego, California, United States of America

Competing Interests

The authors have read the journal's policy and have the following conflicts: Johnson & Johnson Pharmaceutical Research and Development funded this study. Authors are employees of Johnson & Johnson Pharmaceutical Research & Development, LLC or were employees of that firm at the time the research was performed. Studies described here were performed with materials described in Patents/Applications US 7893197 and US 2005074814. This does not alter the authors′ adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SWS STM MC PB. Performed the experiments: LA-J SWS DN MC JS. Analyzed the data: LAJ SWS. Contributed reagents/materials/analysis tools: ES. Wrote the paper: LA-J SWS.