Neighborhood Properties Are Important Determinants of Temperature Sensitive Mutations

Svetlana Lockwood; Bala Krishnamoorthy; Ping Ye

doi:10.1371/journal.pone.0028507

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Open Access

Peer-reviewed

Research Article

Neighborhood Properties Are Important Determinants of Temperature Sensitive Mutations

Svetlana Lockwood,

Affiliations School of Molecular Biosciences, Washington State University, Pullman, Washington, United States of America, School of Electrical Engineering and Computer Science, Washington State University, Pullman, Washington, United States of America
⨯
Bala Krishnamoorthy,

Affiliation Department of Mathematics, Washington State University, Pullman, Washington, United States of America
⨯
Ping Ye

* E-mail: pye@wsu.edu

Affiliation School of Molecular Biosciences, Washington State University, Pullman, Washington, United States of America
⨯

Neighborhood Properties Are Important Determinants of Temperature Sensitive Mutations

Svetlana Lockwood,
Bala Krishnamoorthy,
Ping Ye

Published: December 2, 2011
https://doi.org/10.1371/journal.pone.0028507

About the Authors

Svetlana Lockwood

Affiliations School of Molecular Biosciences, Washington State University, Pullman, Washington, United States of America, School of Electrical Engineering and Computer Science, Washington State University, Pullman, Washington, United States of America

Bala Krishnamoorthy

Affiliation Department of Mathematics, Washington State University, Pullman, Washington, United States of America

Ping Ye

* E-mail: pye@wsu.edu

Affiliation School of Molecular Biosciences, Washington State University, Pullman, Washington, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PY. Performed the experiments: SL BK PY. Analyzed the data: SL BK PY. Contributed reagents/materials/analysis tools: SL BK PY. Wrote the paper: PY.

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Substitution mutation
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Forecasting
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Amino acid substitution
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Crystal structure
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Protein structure prediction
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Gene identification and analysis
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Mutagenesis
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Deletion mutation
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