About the Authors
- Jose Sarmiento
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Affiliations Departments of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, Texas, United States of America, Facultad de Medicina, Instituto de Fisiologia, Universidad Austral de Chile, Valdivia, Chile
- Christie Shumate
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Affiliation Departments of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, Texas, United States of America
- Katsutoshi Suetomi
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Affiliation Multidisciplinary Pain Center, Aichi Medical University, Nagakute, Japan
- Aishwarya Ravindran
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Affiliation Departments of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, Texas, United States of America
- León Villegas
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Affiliation Department of Pharmaceutical Sciences, Universidad Peruana Cayetano Heredia, Lima, Peru
- Krishna Rajarathnam
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Affiliations Departments of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, Texas, United States of America, Sealy Centers for Structural Biology and Molecular Biophysics, and Molecular Medicine, The University of Texas Medical Branch, Galveston, Texas, United States of America
- Javier Navarro
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* E-mail: jnavarro@utmb.edu
Affiliations Departments of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, Texas, United States of America, Sealy Centers for Structural Biology and Molecular Biophysics, and Molecular Medicine, The University of Texas Medical Branch, Galveston, Texas, United States of America
Competing Interests
The authors have declared that no competing interests exist.
Author Contributions
Conceived and designed the experiments: JS JN. Performed the experiments: JS CS KS AR LV. Analyzed the data: JS CS KS AR LV KR JN. Contributed reagents/materials/analysis tools: JS CS KS AR LV KR JN. Wrote the paper: JS JN. Responsible for the functional and binding experiments, including imunocytochemistry, and model development: JS Responsible for the skin inflammation experiments in rabbits: LV Responsible for functional studies in neutrophils: CS The expression of mutant receptors and their functional characterizations: KS Design of the R6 and CC mutants: KR Expressed and purified the R6H and CC mutants: AR.