Molecular Evolution of the Transmembrane Domains of G Protein-Coupled Receptors

Sarosh N. Fatakia; Stefano Costanzi; Carson C. Chow

doi:10.1371/journal.pone.0027813

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Open Access

Peer-reviewed

Research Article

Molecular Evolution of the Transmembrane Domains of G Protein-Coupled Receptors

Sarosh N. Fatakia,

Affiliation Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Stefano Costanzi,

Affiliation Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Carson C. Chow

* E-mail: carsonc@mail.nih.gov

Affiliation Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯

Molecular Evolution of the Transmembrane Domains of G Protein-Coupled Receptors

Sarosh N. Fatakia,
Stefano Costanzi,
Carson C. Chow

Published: November 21, 2011
https://doi.org/10.1371/journal.pone.0027813

About the Authors

Sarosh N. Fatakia

Affiliation Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Stefano Costanzi

Affiliation Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Carson C. Chow

* E-mail: carsonc@mail.nih.gov

Affiliation Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SF SC CC. Analyzed the data: SF SC CC. Wrote the paper: SF SC CC.

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G protein coupled receptors
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Natural selection
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Small molecules
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Lipids
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Nucleotide sequencing
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Mathematical models
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Phylogenetic analysis
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Molecular evolution
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