Toll-like Receptor 3 Regulates Neural Stem Cell Proliferation by Modulating the Sonic Hedgehog Pathway

Kavitha Yaddanapudi; Joari De Miranda; Mady Hornig; W. Ian Lipkin

doi:10.1371/journal.pone.0026766

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Peer-reviewed

Research Article

Toll-like Receptor 3 Regulates Neural Stem Cell Proliferation by Modulating the Sonic Hedgehog Pathway

Kavitha Yaddanapudi ,

Contributed equally to this work with: Kavitha Yaddanapudi, Joari De Miranda

Affiliation Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, United States of America
⨯
Joari De Miranda ,

Contributed equally to this work with: Kavitha Yaddanapudi, Joari De Miranda

Affiliation Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, United States of America
⨯
Mady Hornig,

Affiliation Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, United States of America
⨯
W. Ian Lipkin

* E-mail: wil2001@columbia.edu

Affiliation Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, United States of America
⨯

Toll-like Receptor 3 Regulates Neural Stem Cell Proliferation by Modulating the Sonic Hedgehog Pathway

Kavitha Yaddanapudi,
Joari De Miranda,
Mady Hornig,
W. Ian Lipkin

Published: October 25, 2011
https://doi.org/10.1371/journal.pone.0026766

About the Authors

Kavitha Yaddanapudi

Contributed equally to this work with: Kavitha Yaddanapudi, Joari De Miranda

Affiliation Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, United States of America

Joari De Miranda

Contributed equally to this work with: Kavitha Yaddanapudi, Joari De Miranda

Affiliation Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, United States of America

Mady Hornig

Affiliation Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, United States of America

W. Ian Lipkin

* E-mail: wil2001@columbia.edu

Affiliation Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KY WIL MH JDM. Performed the experiments: KY JDM. Analyzed the data: WIL KY JDM MH. Wrote the paper: KY WIL MH.

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Neurospheres
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Immune receptor signaling
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Signal inhibition
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Apoptosis
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Toll-like receptors
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Flow cytometry
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Precursor cells
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Cell cultures
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