About the Authors

Pierre van Damme

Affiliation Center for the Evaluation of Vaccination, Vaccine & Infectious Disease Institute, University of Antwerp, Antwerp, Belgium

Froukje Kafeja

Affiliation Center for the Evaluation of Vaccination, Vaccine & Infectious Disease Institute, University of Antwerp, Antwerp, Belgium

Alessandra Anemona

Affiliation Novartis Vaccines Institute for Global Health, Siena, Italy

Venere Basile

Affiliation Novartis Vaccines Institute for Global Health, Siena, Italy

Anne Katrin Hilbert

Affiliation Novartis Vaccines & Diagnostics, Clinical Serology Laboratories, Marburg, Germany

Ilse De Coster

Affiliation Center for the Evaluation of Vaccination, Vaccine & Infectious Disease Institute, University of Antwerp, Antwerp, Belgium

Simona Rondini

Affiliation Novartis Vaccines Institute for Global Health, Siena, Italy

Francesca Micoli

Affiliation Novartis Vaccines Institute for Global Health, Siena, Italy

Rana M. Qasim Khan

Affiliation Novartis Vaccines Institute for Global Health, Siena, Italy

Elisa Marchetti

Affiliation Novartis Vaccines Institute for Global Health, Siena, Italy

Vito Di Cioccio

Affiliation Novartis Vaccines Institute for Global Health, Siena, Italy

Allan Saul

Affiliation Novartis Vaccines Institute for Global Health, Siena, Italy

Laura B. Martin

Affiliation Novartis Vaccines Institute for Global Health, Siena, Italy

Audino Podda

audino.podda@novartis.com

Affiliation Novartis Vaccines Institute for Global Health, Siena, Italy

Competing Interests

AA, VB, AKH, SR, FM, RMQK, EM, VDC, AS, LBM, AP are all Novartis employees. AS and AP receive stock options from Novartis. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. PvD, FK and IDC are all employees of Univeristy of Antwerp, Belgium.

Author Contributions

Conceived and designed the experiments: PvD AP AA. Performed the experiments: PvD FK IDC AP AA EM VB RMQK. Analyzed the data: AA. Wrote the paper: PvD AP AA VB AS LBM AKH. Development of the vaccine and production and release of the clinical lot: FM SR VDC LBM AS.