About the Authors

Simon D. Rees

s.d.rees@bham.ac.uk

Affiliations College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, BioMedical Research Centre, Heart of England NHS Foundation Trust, Birmingham, United Kingdom

M. Zafar I. Hydrie

Affiliation Baqai Institute of Diabetology and Endocrinology, Karachi, Pakistan

J. Paul O'Hare

Affiliation Warwick Medical School, University of Warwick, Coventry, United Kingdom

Sudhesh Kumar

Affiliation Warwick Medical School, University of Warwick, Coventry, United Kingdom

A. Samad Shera

Affiliation Diabetic Association of Pakistan, Karachi, Pakistan

Abdul Basit

Affiliation Baqai Institute of Diabetology and Endocrinology, Karachi, Pakistan

Anthony H. Barnett

Affiliations College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, BioMedical Research Centre, Heart of England NHS Foundation Trust, Birmingham, United Kingdom

M. Ann Kelly

Affiliations College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, BioMedical Research Centre, Heart of England NHS Foundation Trust, Birmingham, United Kingdom

Competing Interests

The authors have the following competing interests: This study was partly funded by Eli Lilly. Prof. Sudhesh Kumar has received lecture fees and research funding from Eli Lilly. Prof. Anthony Barnett has received honoraria from Eli Lilly for lectures and advisory work, and has received research funding from Eli Lilly. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MAK. Performed the experiments: SDR. Analyzed the data: SDR. Wrote the paper: SDR MAK. Contributed to discussion and reviewed/edited the manuscript: MZIH JPO SK ASS AB AHB.