The Mechanism of Action of the Histone Deacetylase Inhibitor Vorinostat Involves Interaction with the Insulin-Like Growth Factor Signaling Pathway

Rive Sarfstein; Ilan Bruchim; Ami Fishman; Haim Werner

doi:10.1371/journal.pone.0024468

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Peer-reviewed

Research Article

The Mechanism of Action of the Histone Deacetylase Inhibitor Vorinostat Involves Interaction with the Insulin-Like Growth Factor Signaling Pathway

Rive Sarfstein,

Affiliation Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
⨯
Ilan Bruchim,

Affiliation Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Sava, Israel
⨯
Ami Fishman,

Affiliation Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Sava, Israel
⨯
Haim Werner

* E-mail: hwerner@post.tau.ac.il

Affiliation Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
⨯

The Mechanism of Action of the Histone Deacetylase Inhibitor Vorinostat Involves Interaction with the Insulin-Like Growth Factor Signaling Pathway

Rive Sarfstein,
Ilan Bruchim,
Ami Fishman,
Haim Werner

Published: September 8, 2011
https://doi.org/10.1371/journal.pone.0024468

About the Authors

Rive Sarfstein

Affiliation Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

Ilan Bruchim

Affiliation Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Sava, Israel

Ami Fishman

Affiliation Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Sava, Israel

Haim Werner

* E-mail: hwerner@post.tau.ac.il

Affiliation Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RS IB HW AF. Performed the experiments: RS HW. Analyzed the data: RS IB HW. Contributed reagents/materials/analysis tools: IB AF. Wrote the paper: RS IB AF HW.

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Uterine cancer
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Apoptosis
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Cancer treatment
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Histones
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Phosphorylation
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Cell cycle and cell division
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Cyclins
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Acetylation
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