About the Authors

Dione T. Kobayashi

dkobayashi@smafoundation.org

Affiliation Spinal Muscular Atrophy Foundation, New York, New York, United States of America

Rory J. Olson

Affiliation Enzo Life Sciences Inc., Ann Arbor, Michigan, United States of America

Laurel Sly

Affiliation PharmOptima LLC, Portage, Michigan, United States of America

Chad J. Swanson

Affiliation Spinal Muscular Atrophy Foundation, New York, New York, United States of America

Brett Chung

Affiliation Spinal Muscular Atrophy Foundation, New York, New York, United States of America

Nikolai Naryshkin

Affiliation PTC Therapeutics Inc., South Plainfield, New Jersey, United States of America

Jana Narasimhan

Affiliation PTC Therapeutics Inc., South Plainfield, New Jersey, United States of America

Anuradha Bhattacharyya

Affiliation PTC Therapeutics Inc., South Plainfield, New Jersey, United States of America

Michael Mullenix

Affiliation Enzo Life Sciences Inc., Ann Arbor, Michigan, United States of America

Karen S. Chen

Affiliation Spinal Muscular Atrophy Foundation, New York, New York, United States of America

Competing Interests

The authors have read the journal's policy and have the following conflicts: RJO and MM are employees and shareholders of Enzo Life Sciences Inc.; the company manufactures, markets and sells the SMN ELISA described in this manuscript. NN, JN, and AB are employees of PTC Therapeutics Inc., that develops treatments that may eventually be marketed and whose SMA drug development program is partially funded by the SMA Foundation. LS is an employee of PharmOptima, a contract research organization that was paid by the SMA Foundation to test human and mouse tissues in the SMN ELISA. There are no other patents, products in development, or marketed products to declare. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: DTK RJO CJS NN MM KSC. Performed the experiments: RJO LS JN AB. Analyzed the data: DTK RJO CJS LS NN JN AB BC. Wrote the paper: DTK RJO LS.