About the Authors

Ekaterina M. Nestorovich

Affiliations Department of Biology, The Catholic University of America, Washington, D.C., United States of America, Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America

Vladimir A. Karginov

Affiliation Innovative Biologics, Inc., Herndon, Virginia, United States of America

Michel R. Popoff

Affiliation Department of Host-Pathogen Interactions, Institut Pasteur, Paris, France

Sergey M. Bezrukov

Affiliation Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America

Holger Barth

holger.barth@uni-ulm.de

Affiliation Institute of Pharmacology and Toxicology, University of Ulm Medical Center, Ulm, Germany

Competing Interests

One co-author of this manuscript, Vladimir Karginov (VAK), is an employee and shareholder of Innovative Biologics, Inc. and only provided material (ß-cyclodextrin derivative)for this study. Innovative Biologics, Inc. had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: EMN HB. Performed the experiments: EMN HB. Analyzed the data: EMN HB. Contributed reagents/materials/analysis tools: EMN VAK MRP SMB HB. Wrote the paper: EMN HB.