Brain Region–Specific Decrease in the Activity and Expression of Protein Kinase A in the Frontal Cortex of Regressive Autism

Lina Ji; Ved Chauhan; Michael J. Flory; Abha Chauhan

doi:10.1371/journal.pone.0023751

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Open Access

Peer-reviewed

Research Article

Brain Region–Specific Decrease in the Activity and Expression of Protein Kinase A in the Frontal Cortex of Regressive Autism

Lina Ji,

Affiliations NYS Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America, The State Key Lab of Pharmaceutical Biotechnology, College of Life Sciences, Nanjing University, Nanjing, People's Republic of China
⨯
Ved Chauhan,

Affiliation NYS Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America
⨯
Michael J. Flory,

Affiliation NYS Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America
⨯
Abha Chauhan

* E-mail: abha.chauhan@opwdd.ny.gov

Affiliation NYS Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America
⨯

Brain Region–Specific Decrease in the Activity and Expression of Protein Kinase A in the Frontal Cortex of Regressive Autism

Lina Ji,
Ved Chauhan,
Michael J. Flory,
Abha Chauhan

Published: August 31, 2011
https://doi.org/10.1371/journal.pone.0023751

About the Authors

Lina Ji

Affiliations NYS Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America, The State Key Lab of Pharmaceutical Biotechnology, College of Life Sciences, Nanjing University, Nanjing, People's Republic of China

Ved Chauhan

Affiliation NYS Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America

Michael J. Flory

Affiliation NYS Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America

Abha Chauhan

* E-mail: abha.chauhan@opwdd.ny.gov

Affiliation NYS Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AC. Performed the experiments: LJ. Analyzed the data: AC VC MJF. Contributed reagents/materials/analysis tools: AC. Wrote the paper: AC VC.

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Autism
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Frontal lobe
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Children
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Protein kinases
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Transcription factors
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Cerebellum
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Memory
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