About the Authors

Anna C. Haagsma

Affiliations Department of Molecular Cell Biology, Faculty of Earth and Life Sciences, VU University Amsterdam, Amsterdam, The Netherlands, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Amsterdam, The Netherlands

Ioana Podasca

Affiliations Department of Molecular Cell Biology, Faculty of Earth and Life Sciences, VU University Amsterdam, Amsterdam, The Netherlands, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Amsterdam, The Netherlands

Anil Koul

Affiliation Department of Antimicrobial Research, Tibotec NV, Johnson & Johnson Pharmaceutical Research and Development, Beerse, Belgium

Koen Andries

Affiliation Department of Antimicrobial Research, Tibotec NV, Johnson & Johnson Pharmaceutical Research and Development, Beerse, Belgium

Jerome Guillemont

Affiliation Department of Medicinal Chemistry, Janssen Research & Development, Johnson & Johnson, Val de Reuil, France

Holger Lill

Affiliations Department of Molecular Cell Biology, Faculty of Earth and Life Sciences, VU University Amsterdam, Amsterdam, The Netherlands, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Amsterdam, The Netherlands

Dirk Bald

dirk.bald@falw.vu.nl

Affiliations Department of Molecular Cell Biology, Faculty of Earth and Life Sciences, VU University Amsterdam, Amsterdam, The Netherlands, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Amsterdam, The Netherlands

Competing Interests

The authors have the following competing interest: AK, KA and JG are employees of Tibotec NV. The authors have the following patent to declare for TMC 207: US 7,498,343 B2; date of patent: March, 3, 2009. KA, JG and AK are employees of Tibotec BVBA, a subsidiary of Johnson & Johnson. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: DB. Performed the experiments: ACH IP. Analyzed the data: ACH IP. Contributed reagents/materials/analysis tools: JG AK. Wrote the paper: DB ACH. Provided expertise on drug used: KA. Provided expertise on protein studied: HL.