Reduced cAMP, Akt Activation and p65-c-Rel Dimerization: Mechanisms Involved in the Protective Effects of mGluR3 Agonists in Cultured Astrocytes

Daniela Durand; Lila Carniglia; Carla Caruso; Mercedes Lasaga

doi:10.1371/journal.pone.0022235

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Open Access

Peer-reviewed

Research Article

Reduced cAMP, Akt Activation and p65-c-Rel Dimerization: Mechanisms Involved in the Protective Effects of mGluR3 Agonists in Cultured Astrocytes

Daniela Durand,

Affiliation Research Institute for Reproduction, School of Medicine, University of Buenos Aires, Ciudad Autónoma de Buenos Aires, Beunos Aires, Argentina
⨯
Lila Carniglia,

Affiliation Research Institute for Reproduction, School of Medicine, University of Buenos Aires, Ciudad Autónoma de Buenos Aires, Beunos Aires, Argentina
⨯
Carla Caruso,

Affiliation Research Institute for Reproduction, School of Medicine, University of Buenos Aires, Ciudad Autónoma de Buenos Aires, Beunos Aires, Argentina
⨯
Mercedes Lasaga

* E-mail: mlasaga@fmed.uba.ar

Affiliation Research Institute for Reproduction, School of Medicine, University of Buenos Aires, Ciudad Autónoma de Buenos Aires, Beunos Aires, Argentina
⨯

Reduced cAMP, Akt Activation and p65-c-Rel Dimerization: Mechanisms Involved in the Protective Effects of mGluR3 Agonists in Cultured Astrocytes

Daniela Durand,
Lila Carniglia,
Carla Caruso,
Mercedes Lasaga

Published: July 14, 2011
https://doi.org/10.1371/journal.pone.0022235

About the Authors

Daniela Durand

Affiliation Research Institute for Reproduction, School of Medicine, University of Buenos Aires, Ciudad Autónoma de Buenos Aires, Beunos Aires, Argentina

Lila Carniglia

Affiliation Research Institute for Reproduction, School of Medicine, University of Buenos Aires, Ciudad Autónoma de Buenos Aires, Beunos Aires, Argentina

Carla Caruso

Affiliation Research Institute for Reproduction, School of Medicine, University of Buenos Aires, Ciudad Autónoma de Buenos Aires, Beunos Aires, Argentina

Mercedes Lasaga

* E-mail: mlasaga@fmed.uba.ar

Affiliation Research Institute for Reproduction, School of Medicine, University of Buenos Aires, Ciudad Autónoma de Buenos Aires, Beunos Aires, Argentina

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DD ML. Performed the experiments: DD LC CC. Analyzed the data: DD ML. Contributed reagents/materials/analysis tools: ML. Wrote the paper: DD ML.

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Astrocytes
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Transcription factors
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AKT signaling cascade
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MTT assay
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Nitric oxide
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Co-immunoprecipitation
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Apoptosis
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Adenylyl cyclase signaling cascade
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