About the Authors
- Fredrik Nyberg
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Contributed equally to this work with: Fredrik Nyberg, Atsushi Ogiwara, Chris G. Harbron
* E-mail: Fredrik.Nyberg@astrazeneca.com
Affiliations Global Epidemiology, AstraZeneca R&D, Mölndal, Sweden, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden
- Atsushi Ogiwara
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Contributed equally to this work with: Fredrik Nyberg, Atsushi Ogiwara, Chris G. Harbron
Affiliations Research and Development Division, Medical ProteoScope Company, Tokyo, Japan, Clinical Proteome Center, Tokyo Medical University, Tokyo, Japan
- Chris G. Harbron
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Contributed equally to this work with: Fredrik Nyberg, Atsushi Ogiwara, Chris G. Harbron
Affiliation Discovery Statistics, AstraZeneca R&D, Macclesfield, United Kingdom
- Takao Kawakami
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Affiliations Research and Development Division, Medical ProteoScope Company, Tokyo, Japan, Clinical Proteome Center, Tokyo Medical University, Tokyo, Japan
- Keiko Nagasaka
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Affiliation Research and Development Division, Medical ProteoScope Company, Tokyo, Japan
- Sachiko Takami
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Affiliation Research and Development Division, Medical ProteoScope Company, Tokyo, Japan
- Kazuya Wada
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Affiliation Research and Development Division, Medical ProteoScope Company, Tokyo, Japan
- Hsiao-Kun Tu
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Affiliation Research and Development Division, Medical ProteoScope Company, Tokyo, Japan
- Makiko Otsuji
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Affiliation Research and Development Division, Medical ProteoScope Company, Tokyo, Japan
- Yutaka Kyono
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Affiliation Research and Development Division, Medical ProteoScope Company, Tokyo, Japan
- Tae Dobashi
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Affiliation Research and Development Division, Medical ProteoScope Company, Tokyo, Japan
- Yasuhiko Komatsu
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Affiliation Research and Development Division, Medical ProteoScope Company, Tokyo, Japan
- Makoto Kihara
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Affiliation Research and Development Division, Medical ProteoScope Company, Tokyo, Japan
- Shingo Akimoto
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Affiliations Research and Development Division, Medical ProteoScope Company, Tokyo, Japan, Clinical Proteome Center, Tokyo Medical University, Tokyo, Japan
- Ian S. Peers
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Affiliation Discovery Statistics, AstraZeneca R&D, Macclesfield, United Kingdom
- Marie C. South
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Affiliation Discovery Statistics, AstraZeneca R&D, Macclesfield, United Kingdom
- Tim Higenbottam
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Current address: Chiesi Farmaceutici, Parma, Italy
Affiliation AstraZeneca in Respiratory Biological Sciences, AstraZeneca R&D, Lund, Sweden
- Masahiro Fukuoka
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Affiliation Department of Medical Oncology, Kinki University School of Medicine, Osaka, Japan
- Koichiro Nakata
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Affiliation Nakata Clinic, Tokyo, Japan
- Yuichiro Ohe
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Affiliation Department of Thoracic Oncology, National Cancer Center Hospital East, Chiba, Japan
- Shoji Kudoh
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Affiliations Japan Anti-Tuberculosis Association Fukujuji Hospital, Tokyo, Japan, Division of Pulmonary Medicine, Infectious Diseases and Oncology, Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
- Ib Groth Clausen
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Affiliation Respiratory Biological Sciences, AstraZeneca R&D, Lund, Sweden
- Toshihide Nishimura
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Affiliations Research and Development Division, Medical ProteoScope Company, Tokyo, Japan, Clinical Proteome Center, Tokyo Medical University, Tokyo, Japan
- György Marko-Varga
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Current address: Division of Clinical Protein Science and Imaging, Biomedical Center, Department of Measurement Technology and Industrial Electrical Engineering, Lund University, Lund, Sweden; Department of Surgery, Tokyo Medical University, Tokyo, Japan
Affiliations AstraZeneca in Respiratory Biological Sciences, AstraZeneca R&D, Lund, Sweden, Department of Surgery, Tokyo Medical University, Tokyo, Japan
- Harubumi Kato
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Affiliations Department of Surgery, Tokyo Medical University, Tokyo, Japan, Niizashiki Central General Hospital, Saitama, Japan
Competing Interests
FN, CGH, ISP, MCS and IGC are employees of AstraZeneca and own shares in the company. AO, TK, K. Nagasaka, ST, KW, HKT, MO, Y. Kyono, TD, Y. Komatsu, MK, SA, and TN are/were employees of Medical Proteoscope Co., Ltd. TH is an employee of Chiesi Farmaceutici. TH and GMV are previous employees of AstraZeneca. MF has received honoraria from AstraZeneca. K. Nakata, YO, SK, and HK have declared that no conflicts of interest exist.
Author Contributions
Conceived and designed the experiments: FN AO CGH TK Y. Kyono Y. Komatsu MK SA TH TN MF K. Nakata YO SK GMV HK. Performed the experiments: TK K. Nagasaka ST Y. Kyono TD Y. Komatsu MK. Analyzed the data: FN AO CGH TK ST KW HKT MO Y. Komatsu SA ISP MCS IGC TN GMV. Contributed reagents/materials/analysis tools: AO TK K. Nagasaka ST KW HKT MO Y. Kyono TD Y. Komatsu MK SA MF K. Nakata YO SK HK. Wrote the paper: FN AO CGH TK Y. Komatsu IGC TN GMV. Supervised clinical and epidemiological aspects of the study: FN TH MF K. Nakata YO SK HK. Supervised proteomic aspects of the study: AO TN GMV. Critical review and revision of the manuscript: FN AO CGH TK K. Nagasaka ST KW HKT MO Y. Kyono TD Y. Komatsu MK SA ISP MCS TH MF K. Nakata YO SK IGC TN GMV HK.