About the Authors

Shigeharu Kinoshita

Affiliation Department of Aquatic Bioscience, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo, Tokyo, Japan

Ning Wang

Affiliation Department of Aquatic Bioscience, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo, Tokyo, Japan

Haruka Inoue

Affiliation Department of Aquatic Bioscience, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo, Tokyo, Japan

Kaoru Maeyama

Affiliation Mikimoto Pharmaceutical CO., LTD, Ise, Mie, Japan

Kikuhiko Okamoto

Affiliation Mikimoto Pharmaceutical CO., LTD, Ise, Mie, Japan

Kiyohito Nagai

Affiliation Pearl Research Institute, Mikimoto Co., Ltd, Shima, Mie, Japan

Hidehiro Kondo

Affiliation Laboratory of Genome Science, Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Minato, Tokyo, Japan

Ikuo Hirono

Affiliation Laboratory of Genome Science, Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Minato, Tokyo, Japan

Shuichi Asakawa

Affiliation Department of Aquatic Bioscience, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo, Tokyo, Japan

Shugo Watabe

awatabe@mail.ecc.u-tokyo.ac.jp

Affiliation Department of Aquatic Bioscience, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo, Tokyo, Japan

Competing Interests

The authors declare that some authors are employed by commercial companies: Kaoru Maeyama and Kikuhiko Okamoto are affiliated with Mikimoto Pharmaceutical CO., LTD, Ise, Mie 516-8581, Japan, whereas Kiyohito Nagai is affiliated with Pearl Research Institute, Mikimoto CO., LTD, Shima Mie 517-0403, Japan. The authors declare that this does not alter their adherence to all the PLoS ONE policies on sharing data and materials, as detailed online in your guide for authors http://www.plosone.org/static/policies.action#sharing. They do not have any other relevant declarations relating to employment, consultancy, patents, products in development or marketed products, etc.

Author Contributions

Conceived and designed the experiments: SW. Performed the experiments: SK NW HI HK. Analyzed the data: SK HK SA. Contributed reagents/materials/analysis tools: KM KO KN IH. Wrote the paper: SK SW.