About the Authors

Sarel J. Fleishman

sarelf@uw.edu

Affiliation Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

Andrew Leaver-Fay

Affiliation Department of Biochemistry, University of North Carolina, Chapel Hill, North Carolina, United States of America

Jacob E. Corn

Current address: Genentech, South San Francisco, California, United States of America

Affiliation Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

Eva-Maria Strauch

Affiliation Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

Sagar D. Khare

Affiliation Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

Nobuyasu Koga

Affiliation Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

Justin Ashworth

Current address: Institute for Systems Biology, Seattle, Washington, United States of America

Affiliation Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

Paul Murphy

Affiliation Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

Florian Richter

Affiliation Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

Gordon Lemmon

Affiliation Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America

Jens Meiler

Affiliation Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America

David Baker

Affiliations Department of Biochemistry, University of Washington, Seattle, Washington, United States of America, Howard Hughes Medical Institute, University of Washington, Seattle, Washington, United States of America

Competing Interests

JEC is currently employed by Genentech, but was not during any stage of the work reported here. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SJF ALF JEC EMS SDK NK JA PM FR GL DB JM. Performed the experiments: SJF ALF JEC EMS SDK NK JA PM FR GL. Analyzed the data: SJF ALF JEC EMS SDK NK JA PM FR GL DB. Contributed reagents/materials/analysis tools: SJF ALF JEC EMS SDK NK JA PM FR GL. Wrote the paper: SJF ALF JEC EMS SDK NK JA PM FR GL DB.