About the Authors

Kinyui Alice Lo

Affiliation Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Mary K. Bauchmann

Affiliation Genetically Modified Models Research Center of Emphasis, Pfizer Global Research and Development, Groton, Connecticut, United States of America

Amy P. Baumann

Affiliation Genetically Modified Models Research Center of Emphasis, Pfizer Global Research and Development, Groton, Connecticut, United States of America

Christopher J. Donahue

Affiliation Genetically Modified Models Research Center of Emphasis, Pfizer Global Research and Development, Groton, Connecticut, United States of America

Mark A. Thiede

Affiliation Genetically Modified Models Research Center of Emphasis, Pfizer Global Research and Development, Groton, Connecticut, United States of America

Lisa S. Hayes

Affiliation Cardiovascular, Metabolic and Endocrine Diseases, Pfizer Global Research and Development, Groton, Connecticut, United States of America

Shelley Ann G. des Etages

Affiliation Cardiovascular, Metabolic and Endocrine Diseases, Pfizer Global Research and Development, Groton, Connecticut, United States of America

Ernest Fraenkel

fraenkel-admin@mit.edu

Affiliations Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Competing Interests

MKB APB MAT LH and SGD are Pfizer Inc. shareholders. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: KAL MAT SAGdE EF. Performed the experiments: KAL MKB APB CJD MAT LSH. Analyzed the data: KAL EF. Contributed reagents/materials/analysis tools: KAL MKB APB CJD MAT LSH SAGdE. Wrote the paper: KAL EF.